About: Natural resistance-associated macrophage protein     Goto   Sponge   NotDistinct   Permalink

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Natural resistance-associated macrophage proteins (Nramps), also known as metal ion (Mn2+-iron) transporters (TC# 2.A.55), are a family of metal transport proteins found throughout all domains of life. Taking on an eleven-helix LeuT fold, the Nramp family is a member of the large APC Superfamily of secondary carriers. They transport a variety of transition metals such as manganese, cadmium, and manganese using an alternating access mechanism characteristic of secondary transporters.

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  • Natural resistance-associated macrophage protein (en)
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  • Natural resistance-associated macrophage proteins (Nramps), also known as metal ion (Mn2+-iron) transporters (TC# 2.A.55), are a family of metal transport proteins found throughout all domains of life. Taking on an eleven-helix LeuT fold, the Nramp family is a member of the large APC Superfamily of secondary carriers. They transport a variety of transition metals such as manganese, cadmium, and manganese using an alternating access mechanism characteristic of secondary transporters. (en)
name
  • NRAMP family (en)
foaf:depiction
  • http://commons.wikimedia.org/wiki/Special:FilePath/DraNramp_membrane.png
  • http://commons.wikimedia.org/wiki/Special:FilePath/Nramp.gif
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  • Saier Lab (en)
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date
Pfam
  • PF01566 (en)
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  • Natural resistance-associated macrophage proteins (Nramps), also known as metal ion (Mn2+-iron) transporters (TC# 2.A.55), are a family of metal transport proteins found throughout all domains of life. Taking on an eleven-helix LeuT fold, the Nramp family is a member of the large APC Superfamily of secondary carriers. They transport a variety of transition metals such as manganese, cadmium, and manganese using an alternating access mechanism characteristic of secondary transporters. The name "natural resistance-associated" macrophage proteins arises from the role in resistance of intracellular bacterial pathogens played by some animal homologs. Several human pathologies may result from defects in Nramp-dependent Fe2+ or Mn2+ transport, including iron overload, neurodegenerative diseases and innate susceptibility to infectious diseases. (en)
OPM family
OPM protein
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