New York State Route 153 (NY 153) is a 3.03-mile (4.88 km) long north–south state highway located in the eastern suburbs of Rochester, New York, in the United States. The southern terminus of the route is at NY 96 in the village of Pittsford. Its northern terminus is at an interchange with NY 441 in the town of Penfield. Over the course of its routing, NY 153 passes through the towns of Pittsford, East Rochester (also village), Perinton, and Penfield. NY 153 connects to Interstate 490 (I-490) twice in East Rochester by way of NY 31F and West Commercial Street.