New York State Route 266 (NY 266) is a state highway in Erie County, New York, in the United States. It runs along the Niagara River from the city of Buffalo to the city of Tonawanda. The southern terminus of the route is at the ramps leading to Interstate 190 (I-190) exit 8 in Buffalo. Its northern terminus is at an intersection with NY 265 just south of North Tonawanda in Tonawanda.