About: Nidoviral papain-like protease

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The nidoviral papain-like protease (PLPro or PLP) is a papain-like protease protein domain encoded in the genomes of nidoviruses. It is expressed as part of a large polyprotein from the ORF1a gene and has cysteine protease enzymatic activity responsible for proteolytic cleavage of some of the N-terminal viral nonstructural proteins within the polyprotein. A second protease also encoded by ORF1a, called the 3C-like protease or main protease, is responsible for the majority of further cleavages. Coronaviruses have one or two papain-like protease domains; in SARS-CoV and SARS-CoV-2, one PLPro domain is located in (nsp3). Arteriviruses have two to three PLP domains. In addition to their protease activity, PLP domains function as deubiquitinating enzymes (DUBs) that can cleave the isopeptide b

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein protein
rdfs:label	Nidoviral papain-like protease (en)
rdfs:comment	The nidoviral papain-like protease (PLPro or PLP) is a papain-like protease protein domain encoded in the genomes of nidoviruses. It is expressed as part of a large polyprotein from the ORF1a gene and has cysteine protease enzymatic activity responsible for proteolytic cleavage of some of the N-terminal viral nonstructural proteins within the polyprotein. A second protease also encoded by ORF1a, called the 3C-like protease or main protease, is responsible for the majority of further cleavages. Coronaviruses have one or two papain-like protease domains; in SARS-CoV and SARS-CoV-2, one PLPro domain is located in (nsp3). Arteriviruses have two to three PLP domains. In addition to their protease activity, PLP domains function as deubiquitinating enzymes (DUBs) that can cleave the isopeptide b (en)
name	Coronavirus papain-like peptidase (en)
foaf:depiction
dcterms:subject	Viral proteins Proteases
Wikipage page ID	69492836 (xsd:integer)
Wikipage revision ID	1066204194 (xsd:integer)
Link from a Wikipage to another Wikipage	Antiviral drug Ubiquitin-like protein Deubiquitinating enzyme In vitro Innate immune system ORF1ab Coronavirus SARS-CoV SARS-CoV-2 Essential gene Genome Proteolysis Enzyme Gene MEROPS MERS-CoV Zinc Deubiquitinase Papain Papain-like protease Pathogen Post-translational modification Viral proteins 3C-like protease Cysteine protease Isopeptide bond Protein domain Protease Viral replication Proteases ISG15 Arterivirus Human genome Domains of life Ubiquitin Viral nonstructural protein USP18 Polyprotein Replicase-transcriptase complex Drug target Ubiquitin-like domain Catalytic mechanism Nidovirus N-terminal ORF1a Sequence similarity dbr:Coronavirus_nonstructural_protein_3
sameAs	Nidoviral papain-like protease Nidoviral papain-like protease
dbp:wikiPageUsesTemplate	dbt:Infobox_protein_family dbt:Reflist dbt:PDB
thumbnail	wiki-commons:Special:FilePath/6wzu_sarscov2_plpro.png?width=300
caption	X-ray crystallography structure of the papain-like protease domain from SARS-CoV-2 non-structural protein 3. The catalytic residues are highlighted with cysteine in green and histidine in blue. The blue sphere is a bound zinc ion. From . (en)
InterPro	IPR013016 (en)
Pfam	PF08715 (en)
symbol	CoV_peptidase (en)
has abstract	The nidoviral papain-like protease (PLPro or PLP) is a papain-like protease protein domain encoded in the genomes of nidoviruses. It is expressed as part of a large polyprotein from the ORF1a gene and has cysteine protease enzymatic activity responsible for proteolytic cleavage of some of the N-terminal viral nonstructural proteins within the polyprotein. A second protease also encoded by ORF1a, called the 3C-like protease or main protease, is responsible for the majority of further cleavages. Coronaviruses have one or two papain-like protease domains; in SARS-CoV and SARS-CoV-2, one PLPro domain is located in (nsp3). Arteriviruses have two to three PLP domains. In addition to their protease activity, PLP domains function as deubiquitinating enzymes (DUBs) that can cleave the isopeptide bond found in ubiquitin chains. They are also "deISGylating" enzymes that remove the ubiquitin-like domain interferon-stimulated gene 15 (ISG15) from cellular proteins. These activities are likely responsible for antagonizing the activity of the host innate immune system. Because they are essential for viral replication, papain-like protease domains are considered drug targets for the development of antiviral drugs against human pathogens such as MERS-CoV, SARS-CoV, and SARS-CoV-2. (en)
prov:wasDerivedFrom	wikipedia-en:Nidoviral_papain-like_protease?oldid=1066204194&ns=0
page length (characters) of wiki page	12195 (xsd:nonNegativeInteger)
Symbol	CoV_peptidase
foaf:isPrimaryTopicOf	wikipedia-en:Nidoviral_papain-like_protease
is Link from a Wikipage to another Wikipage of	Nidoviral papain-like protease domain Nidoviral papain-like protein domain
is Wikipage redirect of	Nidoviral papain-like protease domain Nidoviral papain-like protein domain
is foaf:primaryTopic of	wikipedia-en:Nidoviral_papain-like_protease

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