Nomagugu Simelane-Zulu (born 22 August 1976) is a South African lawyer and African National Congress (ANC) politician who has been serving as the KwaZulu-Natal MEC (Member of the Executive Council) for Health since May 2019. She became a Member of the KwaZulu-Natal Legislature in May 2014. She was the chair of the legislature's Agriculture Portfolio Committee from 2014 to 2019. Simelane-Zulu was previously involved in the African National Congress Youth League (ANCYL).