The 12th Nuestra Belleza México pageant, was held at the Antiguo Taller de Locomotoras of Aguascalientes, Aguascalientes, Mexico on September 2, 2005. Thirty-three contestants of the Mexican Republic competed for the national title, which was won by Priscila Perales from Nuevo León, who later competed in Miss Universe 2006 in United States where she was a Semifinalist in the Top 10. Perales was crowned by outgoing Nuestra Belleza México titleholder Laura Elizondo. She was the third Neoleonesa to win this title.