State Route 220 (SR 220) is an east–west state highway in the south central portion of the U.S. state of Ohio. Its western terminus is at SR 772 about 8.25 miles (13.28 km) west of Waverly, and its eastern terminus is at the SR 32/SR 124 concurrency 3 miles (4.8 km) east of Piketon. The entire route is in Pike County.