State Route 350 (SR 350) is a 27.41-mile (44.11 km) east–west state highway in the southwest portion of the U.S. state of Ohio. The highway has its western terminus at SR 123 approximately 2.50 miles (4.02 km) southeast of Lebanon, and just southeast of the interchange Interstate 71 (I-71) has with SR 123 at its exit 32. The eastern terminus of State Route 350 is in New Vienna, following its nearly 2-mile (3.2 km) long concurrency with SR 73, where the two routes meet SR 28 at a signalized intersection.