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About: dbr:Olaparib     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:DrugProduct, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceDrugyago:WikicatPARPInhibitorsyago:Agent114778436yago:Antineoplastic102722458yago:CausalAgent100007347yago:CytotoxicDrug103157987yago:Drug103247620yago:Inhibitor114724436yago:Matter100020827yago:Medicine103740161yago:PhysicalEntity100001930yago:Piperazine103946814drugyago:Substance100020090yago:Vermifuge104528630yago:WikicatExperimentalCancerDrugsyago:WikicatPiperazinesumbel-rc:DrugProduct New Facet based on Instances of this Class

Olaparib, sold under the brand name Lynparza, is a medication for the maintenance treatment of BRCA-mutated advanced ovarian cancer in adults. It is a PARP inhibitor, inhibiting poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair. It acts against cancers in people with hereditary BRCA1 or BRCA2 mutations, which include some ovarian, breast, and prostate cancers. In December 2014, olaparib was approved for use as a single agent by the European Medicines Agency (EMA) in the European Union and by the Food and Drug Administration (FDA) in the United States.