About: Osteostimulation     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:YagoPermanentlyLocatedEntity, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)
QRcode icon
http://dbpedia.demo.openlinksw.com/describe/?url=http%3A%2F%2Fdbpedia.org%2Fresource%2FOsteostimulation&invfp=IFP_OFF&sas=SAME_AS_OFF

Osteostimulation is a technique attempted for improving healing of bone injuries or defects. It has not however been found to be significantly effective in increasing bone healing. It is believed to work through the active stimulation of osteoblast proliferation and differentiation as evidenced by increased levels of DNA synthesis and of the osteoblast markers osteocalcin and alkaline phosphatase. Through an ionic exchange, Bioglass first acts as a scaffolding around and through which new bone forms. In vivo studies have demonstrated that the osteostimulative properties result in stimulation and acceleration of new bone formation in an osseous defect. (FDA 510(k) clearance, February 2006 for PerioGlas).

AttributesValues
rdf:type
rdfs:label
  • Osteostimulation (en)
rdfs:comment
  • Osteostimulation is a technique attempted for improving healing of bone injuries or defects. It has not however been found to be significantly effective in increasing bone healing. It is believed to work through the active stimulation of osteoblast proliferation and differentiation as evidenced by increased levels of DNA synthesis and of the osteoblast markers osteocalcin and alkaline phosphatase. Through an ionic exchange, Bioglass first acts as a scaffolding around and through which new bone forms. In vivo studies have demonstrated that the osteostimulative properties result in stimulation and acceleration of new bone formation in an osseous defect. (FDA 510(k) clearance, February 2006 for PerioGlas). (en)
foaf:depiction
  • http://commons.wikimedia.org/wiki/Special:FilePath/Ostim1.jpg
  • http://commons.wikimedia.org/wiki/Special:FilePath/Ostim2a.jpg
dcterms:subject
Wikipage page ID
Wikipage revision ID
Link from a Wikipage to another Wikipage
sameAs
dbp:wikiPageUsesTemplate
thumbnail
has abstract
  • Osteostimulation is a technique attempted for improving healing of bone injuries or defects. It has not however been found to be significantly effective in increasing bone healing. It is believed to work through the active stimulation of osteoblast proliferation and differentiation as evidenced by increased levels of DNA synthesis and of the osteoblast markers osteocalcin and alkaline phosphatase. Through an ionic exchange, Bioglass first acts as a scaffolding around and through which new bone forms. In vivo studies have demonstrated that the osteostimulative properties result in stimulation and acceleration of new bone formation in an osseous defect. (FDA 510(k) clearance, February 2006 for PerioGlas). Osseous defects, whether from trauma or surgical intervention, all follow a similar healing pattern. Within minutes of defect formation, platelets collect at the site of the injury and adhere to the exposed collagen fibers. The release of the platelet contents stimulates additional platelet aggregation and initiates clot formation.1 This release also has a chemotactic effect and attracts various white blood cells (leukocytes) to the damaged tissues and an acute inflammatory response is initiated. Neutrophils and other leukocytes begin removing any bacteria, foreign material, and dead tissue via a process known as phagocytosis. The inflammatory response and other antigens in the wound also attract lymphocytes. These immune cells release cytokines, such as IL-1 and TNF-α,which can have multiple actions on further physiologic responses. For example, IL-1 amplifies the immune response by inducing the proliferation of T-cells, increases the phagocytic abilities of monocytes and macrophages, and induces the proliferation of fibroblasts. The disruption of the vascular supply, and the subsequent cellular reactions during the inflammatory and immune reactions, result in multiple changes in the local environment, including decreases in pH, oxygen content and the ionic concentrations for calcium, phosphorus, potassium and sodium. If these conditions persist, a chronic inflammatory response may set in, resulting in extensive tissue destruction.2 With respect to implant materials, chronic inflammation and foreign body reactions are associated with the development of a fibrous capsule around the implant. The goal of a graft material is to aid in tissue healing. By moderating pH and ionic concentration changes3, Bioglass may reduce the release or attraction of the immune cells, decreasing the time course and extent of the inflammatory response. Indirect evidence for this has been seen in recent research showing decreased TNF-α4 and elastase5 levels in the presence of Bioglass when compared to controls. (en)
gold:hypernym
prov:wasDerivedFrom
page length (characters) of wiki page
foaf:isPrimaryTopicOf
is Link from a Wikipage to another Wikipage of
is foaf:primaryTopic of
Faceted Search & Find service v1.17_git139 as of Feb 29 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 08.03.3330 as of Mar 19 2024, on Linux (x86_64-generic-linux-glibc212), Single-Server Edition (378 GB total memory, 50 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software