About: Pair-rule gene

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A pair-rule gene is a type of gene involved in the development of the segmented embryos of insects. Pair-rule genes are expressed as a result of differing concentrations of gap gene proteins, which encode transcription factors controlling pair-rule gene expression. Pair-rule genes are defined by the effect of a mutation in that gene, which causes the loss of the normal developmental pattern in alternating segments.

Attributes	Values
rdf:type	yago:Abstraction100002137 yago:Arrangement107938773 yago:Gene105436752 yago:Group100031264 yago:Ordering108456993 protein yago:Sequence108459252 yago:Series108457976 yago:WikicatDevelopmentalGenesAndProteins
rdfs:label	Pair-rule gene (en)
rdfs:comment	A pair-rule gene is a type of gene involved in the development of the segmented embryos of insects. Pair-rule genes are expressed as a result of differing concentrations of gap gene proteins, which encode transcription factors controlling pair-rule gene expression. Pair-rule genes are defined by the effect of a mutation in that gene, which causes the loss of the normal developmental pattern in alternating segments. (en)
foaf:depiction
dcterms:subject	Developmental genes and proteins
Wikipage page ID	13976171 (xsd:integer)
Wikipage revision ID	1112986103 (xsd:integer)
Link from a Wikipage to another Wikipage	Mutation Gene expression Genetic screen Christiane Nüsslein-Volhard Embryos Gene Transcription factors Drosophila embryogenesis Drosophila melanogaster Gap gene Anatomical terms of location Developmental genes and proteins Insects Segmentation (biology) Eric Wieschaus Development (biology)
Link from a Wikipage to an external page	http://www.sdbonline.org/fly/aignfam/gapnprl.htm
sameAs	Pair-rule gene Pair-rule gene Pair-rule gene Pair-rule gene Pair-rule gene
dbp:wikiPageUsesTemplate	dbt:Reflist
thumbnail	wiki-commons:Special:FilePath/Even-skipped_fushi_tarazu.svg?width=300
has abstract	A pair-rule gene is a type of gene involved in the development of the segmented embryos of insects. Pair-rule genes are expressed as a result of differing concentrations of gap gene proteins, which encode transcription factors controlling pair-rule gene expression. Pair-rule genes are defined by the effect of a mutation in that gene, which causes the loss of the normal developmental pattern in alternating segments. Pair-rule genes were first described by Christiane Nüsslein-Volhard and Eric Wieschaus in 1980. They used a genetic screen to identify genes required for embryonic development in the fruit fly Drosophila melanogaster. In normal unmutated Drosophila, each segment produces bristles called denticles in a band arranged on the side of the segment closer to the head (the anterior). They found five genes – even-skipped, hairy, odd-skipped, paired and runt – where mutations caused the deletion of a particular region of every alternate segment. For example, in even-skipped, the denticle bands of alternate segments are missing, which results in an embryo having half the number of denticle bands. Later work identified more pair-rule genes in the Drosophila early embryo – fushi tarazu, odd-paired and sloppy paired. Once the pair-rule genes had been identified at the molecular level it was found that each gene is expressed in alternate parasegments – regions in the embryo that are closely related to segments, but are slightly out of register. Each parasegment includes the posterior part of one (future) segment, and an anterior part of the next (more posterior) segment. The bands of expression of the pair-rule genes correspond to the regions missing in the mutant. The expression of the pair-rule genes in bands is dependent both upon direct regulation by the gap genes and on regulatory interactions between the pair-rule genes themselves. (en)
gold:hypernym	Gene
prov:wasDerivedFrom	wikipedia-en:Pair-rule_gene?oldid=1112986103&ns=0
page length (characters) of wiki page	5749 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Pair-rule_gene
is Link from a Wikipage to another Wikipage of	FTZ (disambiguation) JAK-STAT signaling pathway Genome (book) Embryology Krüppel Regional differentiation Gap gene Germ-band extension AF4/FMR2 family Hox gene Segmentation (biology) Evolutionary developmental biology Evx1 Steroidogenic factor 1 Segment polarity gene Pair-rule genes Pair rule Pair rule gene Pair rule genes Pairrule gene Fushi Tarazu Fushi tarazu
is Wikipage redirect of	Pair-rule genes Pair rule Pair rule gene Pair rule genes Pairrule gene Fushi Tarazu Fushi tarazu
is foaf:primaryTopic of	wikipedia-en:Pair-rule_gene

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