About: Pan-cancer analysis

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Pan-cancer analysis aims to examine the similarities and differences among the genomic and cellular alterations found across diverse tumor types. International efforts have performed pan-cancer analysis on exomes and the whole genomes of cancers, the latter including their non-coding regions. In 2018, The Cancer Genome Atlas (TCGA) Research Network used exome, transcriptome, and DNA methylome data to develop an integrated picture of commonalities, differences, and emergent themes across tumor types.

Attributes	Values
rdfs:label	Pan-cancer analysis (en) 全基因组泛癌分析 (zh)
rdfs:comment	全基因组泛癌分析（英语：Pan-Cancer Analysis of Whole Genomes，PCAWG）是由国际癌症基因组联盟（ICGC）组织的一个国际性合作项目，对超过2600组癌细胞基因进行分析。 (zh) Pan-cancer analysis aims to examine the similarities and differences among the genomic and cellular alterations found across diverse tumor types. International efforts have performed pan-cancer analysis on exomes and the whole genomes of cancers, the latter including their non-coding regions. In 2018, The Cancer Genome Atlas (TCGA) Research Network used exome, transcriptome, and DNA methylome data to develop an integrated picture of commonalities, differences, and emergent themes across tumor types. (en)
dcterms:subject	Cancer research
Wikipage page ID	41906589 (xsd:integer)
Wikipage revision ID	1075679185 (xsd:integer)
Link from a Wikipage to another Wikipage	BYSL Metabolomics Ontario Institute for Cancer Research Cancer research International Cancer Genome Consortium Proteomics Tumors Competing endogenous RNA (ceRNA) databases and resources Genome RBMS3 Genomics Copy number variation ZC3H13 Machine learning StarBase (biological database) The Cancer Genome Atlas MicroRNA and microRNA target database Omics Tumor ZGPAT Long non-coding RNA database European Bioinformatics Institute European Molecular Biology Laboratory Exome Carcinogenesis ELAC1 National Center for Biotechnology Information RNA-binding protein Single-nucleotide polymorphism Transcriptome Methylome dbr:NSUN6
Link from a Wikipage to an external page	http://starbase.sysu.edu.cn/panCancer.php https://ocg.cancer.gov/programs/target/data-matrix https://proteinpaint.stjude.org/ https://www.embl.de/campaigns/pancancer/index.html http://www.nature.com/collections/PCAWG
sameAs	Pan-cancer analysis Pan-cancer analysis Pan-cancer analysis
dbp:wikiPageUsesTemplate	dbt:Reflist dbt:Short_description
has abstract	Pan-cancer analysis aims to examine the similarities and differences among the genomic and cellular alterations found across diverse tumor types. International efforts have performed pan-cancer analysis on exomes and the whole genomes of cancers, the latter including their non-coding regions. In 2018, The Cancer Genome Atlas (TCGA) Research Network used exome, transcriptome, and DNA methylome data to develop an integrated picture of commonalities, differences, and emergent themes across tumor types. In 2020, the International Cancer Genome Consortium (ICGC)/TCGA Pan-Cancer Analysis of Whole Genomes project published a set of 24 papers analyzing whole cancer genomes and transcriptomic data from 38 tumor types. A comprehensive overview of the project is provided in its flagship paper. Another project, pan-cancer analysis of RNA-binding proteins (RBPs) across human cancers, explored the expression, somatic copy number alteration, and mutation profiles of 1,542 RBPs in ∼7,000 clinical specimens across 15 cancer types. This study characterized the oncogenic properties of six RBPs—, ZC3H13, BYSL, ELAC1, RBMS3, and ZGPAT—in colorectal and liver cancer cell lines. Several studies have found a causal, predictable connection between genomic alterations (single-nucleotide variants or large copy number variants) and gene expression across all tumor types. This pan-cancer relationship between genomic status and transcriptomic quantitative data can predict a specific genomic alteration from gene expression profiles alone; it can also be used as the basis for machine learning approaches. (en) 全基因组泛癌分析（英语：Pan-Cancer Analysis of Whole Genomes，PCAWG）是由国际癌症基因组联盟（ICGC）组织的一个国际性合作项目，对超过2600组癌细胞基因进行分析。 (zh)
prov:wasDerivedFrom	wikipedia-en:Pan-cancer_analysis?oldid=1075679185&ns=0
page length (characters) of wiki page	6771 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Pan-cancer_analysis
is Link from a Wikipage to another Wikipage of	Mutational signatures Pan-Cancer Analysis Interferon type I
is Wikipage redirect of	Pan-Cancer Analysis
is foaf:primaryTopic of	wikipedia-en:Pan-cancer_analysis

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