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Pannexins (from Greek 'παν' — all, and from Latin 'nexus' — connection) are a family of vertebrate proteins identified by their homology to the invertebrate innexins. While innexins are responsible for forming gap junctions in invertebrates, the pannexins have been shown to predominantly exist as large transmembrane channels connecting the intracellular and extracellular space, allowing the passage of ions and small molecules between these compartments (such as ATP and sulforhodamine B). Three pannexins have been described in Chordates: Panx1, Panx2 and Panx3.

AttributesValues
rdf:type
rdfs:label
  • Pannexine (de)
  • Pannexina (it)
  • Pannexin (en)
  • Паннексины (ru)
rdfs:comment
  • Pannexine sind Mitglieder einer Proteinfamilie in Tieren, die an verschiedenen Stellen des menschlichen Körpers nachweisbar und mit der Familie der Connexine verwandt sind. Es handelt sich um Strukturproteine, die aus einigen Hundert Aminosäure-Bausteinen aufgebaut sind. Pannexine bilden in Erythrozyten ATP-Kanäle, sind an der Ausschüttung von Interleukin-1 beteiligt und formen im Gehirn Gap junctions. Eine Rolle in der Karzinogenese wird diskutiert. Beim Menschen sind drei Pannexine bekannt: (de)
  • Pannexins (from Greek 'παν' — all, and from Latin 'nexus' — connection) are a family of vertebrate proteins identified by their homology to the invertebrate innexins. While innexins are responsible for forming gap junctions in invertebrates, the pannexins have been shown to predominantly exist as large transmembrane channels connecting the intracellular and extracellular space, allowing the passage of ions and small molecules between these compartments (such as ATP and sulforhodamine B). Three pannexins have been described in Chordates: Panx1, Panx2 and Panx3. (en)
  • Le pannexine (dal greco παν, pan, "tutto" e dal latino nexus, "connessione") costituiscono una famiglia di proteine dei vertebrati, con funzioni omologhe a quelle delle innexine degli invertebrati. Mentre le innexine sono la causa della formazione delle gap junctions negli invertebrati, le pannexine appaiono principalmente sotto forma di ampi canali di connessione tra gli spazi intracellulari ed extracellulari, che permettono il passaggio di ioni e di piccole molecole, come l'ATP e la , tra i due compartimenti. Nei Cordati sono state descritte tre pannexine: la Panx1, la Panx2 e la Panx3. (it)
  • Паннексины — группа общих белков позвоночных и беспозвоночных, схожих по строению с коннексинами (белками щелевых каналов позвоночных) и иннексинами (белками, образующими каналы у беспозвоночных). Если коннексины преимущественно используются для образования щелевых контактов, то паннексины используются как большие трансмембранные каналы, соединяющие внутриклеточное и внеклеточное пространство и способные пропускать ионы и малые молекулы, такие как АТФ, между этих двух сред. (ru)
foaf:name
  • pannexin 1 (en)
  • pannexin 2 (en)
  • pannexin 3 (en)
name
  • Pannexin (en)
  • pannexin 1 (en)
  • pannexin 2 (en)
  • pannexin 3 (en)
dcterms:subject
Wikipage page ID
Wikipage revision ID
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Link from a Wikipage to an external page
sameAs
TCDB
dbp:wikiPageUsesTemplate
OMIM
InterPro
  • IPR039099 (en)
symbol
  • PANX1 (en)
  • Pannexin (en)
  • PANX2 (en)
  • PANX3 (en)
UniProt
  • Q96QZ0 (en)
  • Q96RD6 (en)
  • Q96RD7 (en)
has abstract
  • Pannexine sind Mitglieder einer Proteinfamilie in Tieren, die an verschiedenen Stellen des menschlichen Körpers nachweisbar und mit der Familie der Connexine verwandt sind. Es handelt sich um Strukturproteine, die aus einigen Hundert Aminosäure-Bausteinen aufgebaut sind. Pannexine bilden in Erythrozyten ATP-Kanäle, sind an der Ausschüttung von Interleukin-1 beteiligt und formen im Gehirn Gap junctions. Eine Rolle in der Karzinogenese wird diskutiert. Beim Menschen sind drei Pannexine bekannt: (de)
  • Pannexins (from Greek 'παν' — all, and from Latin 'nexus' — connection) are a family of vertebrate proteins identified by their homology to the invertebrate innexins. While innexins are responsible for forming gap junctions in invertebrates, the pannexins have been shown to predominantly exist as large transmembrane channels connecting the intracellular and extracellular space, allowing the passage of ions and small molecules between these compartments (such as ATP and sulforhodamine B). Three pannexins have been described in Chordates: Panx1, Panx2 and Panx3. (en)
  • Le pannexine (dal greco παν, pan, "tutto" e dal latino nexus, "connessione") costituiscono una famiglia di proteine dei vertebrati, con funzioni omologhe a quelle delle innexine degli invertebrati. Mentre le innexine sono la causa della formazione delle gap junctions negli invertebrati, le pannexine appaiono principalmente sotto forma di ampi canali di connessione tra gli spazi intracellulari ed extracellulari, che permettono il passaggio di ioni e di piccole molecole, come l'ATP e la , tra i due compartimenti. Nei Cordati sono state descritte tre pannexine: la Panx1, la Panx2 e la Panx3. (it)
  • Паннексины — группа общих белков позвоночных и беспозвоночных, схожих по строению с коннексинами (белками щелевых каналов позвоночных) и иннексинами (белками, образующими каналы у беспозвоночных). Если коннексины преимущественно используются для образования щелевых контактов, то паннексины используются как большие трансмембранные каналы, соединяющие внутриклеточное и внеклеточное пространство и способные пропускать ионы и малые молекулы, такие как АТФ, между этих двух сред. (ru)
Arm
  • q (en)
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