About: Para-Chloromethamphetamine     Goto   Sponge   NotDistinct   Permalink

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para-Chloromethamphetamine (also known as 4-chloromethamphetamine and 4-CMA) is a stimulant that is the N-methyl derivative and prodrug of the neurotoxic drug para-chloroamphetamine (4-CA). It has been found to decrease serotonin in rats. Further investigation into the long-term effects of chloroamphetamines discovered that administration of 4-CMA caused a prolonged reduction in the levels of serotonin and the activity of tryptophan hydroxylase in the brain one month after injection of a single dose of the drug.

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rdfs:label
  • Para-Chloromethamphetamine (en)
rdfs:comment
  • para-Chloromethamphetamine (also known as 4-chloromethamphetamine and 4-CMA) is a stimulant that is the N-methyl derivative and prodrug of the neurotoxic drug para-chloroamphetamine (4-CA). It has been found to decrease serotonin in rats. Further investigation into the long-term effects of chloroamphetamines discovered that administration of 4-CMA caused a prolonged reduction in the levels of serotonin and the activity of tryptophan hydroxylase in the brain one month after injection of a single dose of the drug. (en)
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  • para-Chloromethamphetamine (en)
foaf:depiction
  • http://commons.wikimedia.org/wiki/Special:FilePath/4-CMA_structure.png
  • http://commons.wikimedia.org/wiki/Special:FilePath/Tablet_containing_4-chloromethamphetamine.jpg
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drug name
  • para-Chloromethamphetamine (en)
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IUPAC name
legal DE
  • NpSG (en)
legal UK
  • Class B (en)
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PubChem
SMILES
  • ClC1=CC=CCCNC (en)
StdInChI
StdInChIKey
  • XXLWNLKEOWWHDC-UHFFFAOYSA-N (en)
UNII
  • IXP5G5WMYA (en)
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has abstract
  • para-Chloromethamphetamine (also known as 4-chloromethamphetamine and 4-CMA) is a stimulant that is the N-methyl derivative and prodrug of the neurotoxic drug para-chloroamphetamine (4-CA). It has been found to decrease serotonin in rats. Further investigation into the long-term effects of chloroamphetamines discovered that administration of 4-CMA caused a prolonged reduction in the levels of serotonin and the activity of tryptophan hydroxylase in the brain one month after injection of a single dose of the drug. Another study on rats found that 4-chloromethamphetamine was more potent at inducing conditioned taste aversion than methamphetamine. 4-Chloromethamphetamine was further investigated in the 1960s along with 4-CA and it was noted that they differed from their parent amphetamine and methamphetamine substances by exhibiting only a slight central stimulant effect in both animals and humans and that they acted like antidepressants rather than stimulants. 4-Chloromethamphetamine was identified outside of the laboratory for the first time at the Tomorrowland festival edition 2015, where a tablet was found in possession of a drug dealer (see picture). (en)
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CAS number
  • 30572-91-9
FDA UNII code
  • IXP5G5WMYA
PubChem
  • 3128
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