Paul-Henri Spence (November 9, 1906 – May 29, 1994) was a Quebec businessman and politician. Spence was born in Roberval, Quebec and was an accountant by training. He was elected to the House of Commons of Canada in a 1952 by-election in Roberval's federal constituency to become only the third Progressive Conservative MP from Quebec to sit in the 21st Canadian Parliament. He only sat in Parliament for a year before he lost his seat in the 1953 general election with Liberal Georges Villeneuve defeating him by just over 200 votes.