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Pegaptanib sodium injection (brand name Macugen) is an anti-angiogenic medicine for the treatment of neovascular (wet) age-related macular degeneration (AMD). It was discovered by (which merged with Gilead Sciences in 1999) and licensed in 2000 to EyeTech Pharmaceuticals, now OSI Pharmaceuticals, for late stage development and marketing in the United States. Gilead Sciences continues to receive royalties from the drugs licensing. Outside the US pegaptanib is marketed by Pfizer. Approval was granted by the U.S. Food and Drug Administration (FDA) in December 2004.

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  • Pegaptanib (de)
  • Pegaptanib (es)
  • ペガプタニブ (ja)
  • Pegaptanib (en)
  • Pegaptanib (pl)
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  • Pegaptanib es un medicamento de tipo aptámero que se utiliza en oftalmología para el tratamiento de la degeneración macular asociada a la edad (DMAE) en su forma húmeda o exudativa. No es útil en la forma seca que es la que presenta el 90% de los pacientes aquejados de esta enfermedad.​ (es)
  • Pegaptanib (Akronym aus dem engl. PEGylated aptamer angiogenesis inhibitor) ist ein Hemmstoff des vaskulären endothelialen Wachstumsfaktors (VEGF-Inhibitor) und dient zur Behandlung der feuchten altersabhängigen Makuladegeneration (AMD), einer Erkrankung des Auges. Pegaptanib ist ein PEGyliertes, 2'-Fluor-Pyrimidin und 2'-O-Methyl-Purin substituiertes 27mer RNA-Aptamer und war im Dezember 2004 das erste von der FDA zugelassene Aptamer. Mit der Einführung von überlegenen Therapieformen hat der Wirkstoff an Bedeutung verloren. In Deutschland wurde er deswegen vom Markt genommen. (de)
  • Pegaptanib sodium injection (brand name Macugen) is an anti-angiogenic medicine for the treatment of neovascular (wet) age-related macular degeneration (AMD). It was discovered by (which merged with Gilead Sciences in 1999) and licensed in 2000 to EyeTech Pharmaceuticals, now OSI Pharmaceuticals, for late stage development and marketing in the United States. Gilead Sciences continues to receive royalties from the drugs licensing. Outside the US pegaptanib is marketed by Pfizer. Approval was granted by the U.S. Food and Drug Administration (FDA) in December 2004. (en)
  • ペガプタニブナトリウム(Pegaptanib sodium)注射剤(商品名:マクジェン)は、抗血管新生作用を有する滲出型加齢黄斑変性症(AMD)の治療薬である。本剤は、NeXstar Pharmaceuticals社(1999年にギリアド・サイエンシズ社と合併)によって発見され、2000年にEyeTech Pharmaceuticals社(現OSI Pharmaceuticals社)にライセンスされ、米国での後期開発および販売を行っている。ギリアド・サイエンシズ社は医薬品のライセンスからのロイヤルティを継続して受け取っている。米国外では、ペガプタニブはファイザー社が販売している。2004年12月に米国食品医薬品局(FDA)より承認を取得した。2008年7月には日本でも承認された。日本初の「核酸医薬」である。 (ja)
  • Pegaptanib (łac. pegaptanibbum) – wielofunkcyjny organiczny związek chemiczny, oligonukleotydowy aptamer, stosowany w leczeniu neowaskularnej (wysiękowej) postaci zwyrodnienia plamki żółtej związanego z wiekiem (AMD). (pl)
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  • Pegaptanib sodium (en)
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