The Peirce Mansion is a 23-room mansion located in Sioux City, Iowa. From 1960 until 2011, the mansion was home to the Sioux City Public Museum with exhibits relating to the history of the region. It is still owned by the Sioux City Public Museum and has now been restored to a Victorian-era appearance. It is open to the public for quarterly open house events and is available for rental. The mansion was listed on the National Register of Historic Places in 1978.