Pennsylvania Route 216 (PA 216) is a 26-mile-long (42 km) state highway located in York County, Pennsylvania. The western terminus is at PA 116 near Hanover. The eastern terminus is at PA 24 in Winterstown. PA 216 is a two-lane undivided road that passes through rural areas in southern York County, serving and Glen Rock. The route intersects PA 516 in Sticks, PA 616 in Glen Rock, and Interstate 83 (I-83) near Loganville.