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About: Phillip Thomas Hawkins     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatAcademicsOfTheUniversityOfCambridge, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: Thingpersonyago:WikicatBritishImmunologistsyago:WikicatBritishScientistsyago:WikicatLivingPeopleyago:Academician109759069yago:Adult109605289yago:CausalAgent100007347yago:Educator110045713yago:Immunologist110199902yago:LivingThing100004258yago:MedicalScientist110306004yago:Object100002684yago:Organism100004475yago:Person100007846yago:PhysicalEntity100001930yago:Professional110480253yago:YagoLegalActoryago:YagoLegalActorGeoyago:Scientist110560637yago:Whole100003553yago:WikicatAcademicsOfTheUniversityOfCambridge New Facet based on Instances of this Class

Phillip (Phill) Thomas Hawkins FRS (born 5 October 1958) is a molecular biologist, senior group leader at the Babraham Institute. Phill Hawkins has contributed much to the understanding of inositol lipids functions in eukaryotic cells. Together with his long-time collaborator Leonard R Stephens, he established that PtdIns(4,5)P2 is the main substrate of receptor-controlled Type 1 phosphoinositide 3-kinases (PI3Ks), thus identifying PtdIns(3,4,5)P3 as the key output signal produced by this enzyme.They identified and isolated the GPCR-activated Type 1B PI3K (PI3KΥ) and, in a sustained body of work, defined its structure, explained its complex pattern of regulation by GβΥ and Ras, and proved its role in inflammatory events in vivo. They - in parallel with Dario Alessi - identified phosphoinos