Phoslactomycin (PLM) is a natural product from the isolation of Streptomyces species. This is an inhibitor of the protein which is the protein phosphate 2A (PP2A). The PP2A involves the growth factor of the cell such as to induce the formation of mitogen-activated protein interaction and playing a role in cell division and signal transduction. Therefore, PLM is used for the drug that prevents the tumor, cancer, or bacteria. There are nowsaday has 7 kinds of different PLM from PLM A to PLM G which differ the post-synthesis from the biosynthesis of PLM.
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| - Phoslactomycin (PLM) is a natural product from the isolation of Streptomyces species. This is an inhibitor of the protein which is the protein phosphate 2A (PP2A). The PP2A involves the growth factor of the cell such as to induce the formation of mitogen-activated protein interaction and playing a role in cell division and signal transduction. Therefore, PLM is used for the drug that prevents the tumor, cancer, or bacteria. There are nowsaday has 7 kinds of different PLM from PLM A to PLM G which differ the post-synthesis from the biosynthesis of PLM. (en)
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| - Phoslactomycin (en)
- Phoslactomycin B1 (en)
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| - Phoslactomycin B1.png (en)
- Phoslactomycin.png (en)
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| - File:Phospholactomycin_B.png (en)
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| - Phoslactomycin (PLM) is a natural product from the isolation of Streptomyces species. This is an inhibitor of the protein which is the protein phosphate 2A (PP2A). The PP2A involves the growth factor of the cell such as to induce the formation of mitogen-activated protein interaction and playing a role in cell division and signal transduction. Therefore, PLM is used for the drug that prevents the tumor, cancer, or bacteria. There are nowsaday has 7 kinds of different PLM from PLM A to PLM G which differ the post-synthesis from the biosynthesis of PLM. Phoslactomycin B (PLM B) is the product of the post synthase of the biosynthesis of phoslactomycin and the intermediate to produce the other PLMs. The biosynthesis of phoslactomycin belongs to type I polyketide synthase (PKS). A polyketide is are characterized by a macrocyclic lactone and is produced by bacteria and fungi. From the PLM B, there are many articles wrote about the synthesis of different PLM A through PLM G. (en)
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alternative name
| - 2H-Pyran-2-one, 6-(3-(2-aminoethyl)-10-cyclohexyl-3,6-dihydroxy-4-(phosphonooxy)-1,7,9-decatrienyl)-5-ethyl-5,6-dihydro- (en)
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IUPAC name
| - (1E,3R,4R,6R,7Z,9Z)-3-(2-Aminoethyl)-10-cyclohexyl-1-[(2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-3,6-dihydroxydeca-1,7,9-trien-4-yl dihydrogen phosphate (en)
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