Photoaffinity labeling is a chemoproteomics technique used to attach "labels" to the active site of a large molecule, especially a protein. The "label" attaches to the molecule loosely and reversibly, and has an inactive site which can be converted using photolysis into a highly reactive form, which causes the label to bind more permanently to the large molecule via a covalent bond. The technique was first described in the 1970s. Molecules that have been used as labels in this process are often analogs of complex molecules, in which certain functional groups are replaced with a photoreactive group, such as an azide, a diazirine or a benzophenone.
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| - Photoaffinitätsmarkierung (de)
- Photoaffinity labeling (en)
- Фоточутливе мічення (uk)
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| - Eine Photoaffinitätsmarkierung ist eine biochemische Methode zur Molekülmarkierung durch einen UV-Licht-aktivierten Label-Transfer oder eine Vernetzung eines Moleküls nach Bindung eines anderen Moleküls in vivo oder in vitro. (de)
- Photoaffinity labeling is a chemoproteomics technique used to attach "labels" to the active site of a large molecule, especially a protein. The "label" attaches to the molecule loosely and reversibly, and has an inactive site which can be converted using photolysis into a highly reactive form, which causes the label to bind more permanently to the large molecule via a covalent bond. The technique was first described in the 1970s. Molecules that have been used as labels in this process are often analogs of complex molecules, in which certain functional groups are replaced with a photoreactive group, such as an azide, a diazirine or a benzophenone. (en)
- Фоточутливе мічення (англ. photoaffinity labeling, рос. фоточувствительное мечение) — метод, що полягає на прикріпленні фотореактивної молекулярної частинки до біомолекули. Метод був вперше описаний в 1970-тих роках. (uk)
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| - Eine Photoaffinitätsmarkierung ist eine biochemische Methode zur Molekülmarkierung durch einen UV-Licht-aktivierten Label-Transfer oder eine Vernetzung eines Moleküls nach Bindung eines anderen Moleküls in vivo oder in vitro. (de)
- Photoaffinity labeling is a chemoproteomics technique used to attach "labels" to the active site of a large molecule, especially a protein. The "label" attaches to the molecule loosely and reversibly, and has an inactive site which can be converted using photolysis into a highly reactive form, which causes the label to bind more permanently to the large molecule via a covalent bond. The technique was first described in the 1970s. Molecules that have been used as labels in this process are often analogs of complex molecules, in which certain functional groups are replaced with a photoreactive group, such as an azide, a diazirine or a benzophenone. (en)
- Фоточутливе мічення (англ. photoaffinity labeling, рос. фоточувствительное мечение) — метод, що полягає на прикріпленні фотореактивної молекулярної частинки до біомолекули. Метод був вперше описаний в 1970-тих роках. (uk)
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