Pierre Defraigne was executive director for the Brussels-based think tank the Madariaga - College of Europe Foundation. From 1970 to 2005 he served as a European civil servant as head of cabinet for Étienne Davignon (EU Commission vice-president 1977–1983), director for North–South relations, Pascal Lamy's (EU Commissioner for Trade 1999–2002), head of cabinet and deputy director-general at DG Trade, European Commission. From 2005 to 2008 Defraigne also established and managed the Brussels branch of the Institut français des relations internationales (IFRI).
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