PiggyBac Transposable Element Derived 5 is an enzyme that in humans is encoded by the PGBD5 gene. PGBD5 is a DNA transposase related to the ancient PiggyBac transposase first identified in the cabbage looper moth, Trichoplusia ni. The gene is believed to have been domesticated over 500 million years ago in the common ancestor of cephalochordates and vertebrates. The putative catalytic triad of the protein composed of three aspartic acid residues is conserved among PGBD5-like genes through evolution, and is distinct from other PiggyBac-like genes. PGBD5 has been shown to be able to transpose DNA in a sequence-specific, cut-and-paste fashion. PGBD5 has also been proposed to mediate site-specific DNA rearrangements in human tumors.
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| - PiggyBac Transposable Element Derived 5 (en)
- PGBD5 (uk)
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| - PGBD5 (англ. PiggyBac transposable element derived 5) — білок, який кодується однойменним геном, розташованим у людей на 1-й хромосомі. Довжина поліпептидного ланцюга білка становить 455 амінокислот, а молекулярна маса — 51 642. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Локалізований у мембрані. (uk)
- PiggyBac Transposable Element Derived 5 is an enzyme that in humans is encoded by the PGBD5 gene. PGBD5 is a DNA transposase related to the ancient PiggyBac transposase first identified in the cabbage looper moth, Trichoplusia ni. The gene is believed to have been domesticated over 500 million years ago in the common ancestor of cephalochordates and vertebrates. The putative catalytic triad of the protein composed of three aspartic acid residues is conserved among PGBD5-like genes through evolution, and is distinct from other PiggyBac-like genes. PGBD5 has been shown to be able to transpose DNA in a sequence-specific, cut-and-paste fashion. PGBD5 has also been proposed to mediate site-specific DNA rearrangements in human tumors. (en)
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| - PiggyBac Transposable Element Derived 5 is an enzyme that in humans is encoded by the PGBD5 gene. PGBD5 is a DNA transposase related to the ancient PiggyBac transposase first identified in the cabbage looper moth, Trichoplusia ni. The gene is believed to have been domesticated over 500 million years ago in the common ancestor of cephalochordates and vertebrates. The putative catalytic triad of the protein composed of three aspartic acid residues is conserved among PGBD5-like genes through evolution, and is distinct from other PiggyBac-like genes. PGBD5 has been shown to be able to transpose DNA in a sequence-specific, cut-and-paste fashion. PGBD5 has also been proposed to mediate site-specific DNA rearrangements in human tumors. Human PGBD5 can mobilize the insect PiggyBac transposons in human cell culture. (en)
- PGBD5 (англ. PiggyBac transposable element derived 5) — білок, який кодується однойменним геном, розташованим у людей на 1-й хромосомі. Довжина поліпептидного ланцюга білка становить 455 амінокислот, а молекулярна маса — 51 642. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Локалізований у мембрані. (uk)
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