The pre-integration complex (PIC) is a nucleoprotein complex of viral genetic material and associated viral and host proteins which is capable of inserting a viral genome into a host genome. The PIC forms after uncoating of a viral particle after entry into the host cell. In the case of the human immunodeficiency virus (HIV), the PIC forms after the Reverse Transcription Complex (RTC) has reverse transcribed the viral RNA into DNA. The PIC consists of viral proteins (including Vpr, matrix and integrase), host proteins (including Barrier to autointegration factor 1) and the viral DNA. The PIC enters the cellular nucleus through the nuclear pore complex without disrupting the nuclear envelope, thus allowing HIV and related retroviruses to replicate in non-dividing cells. Following nuclear en
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| - Complejo de preintegración (es)
- Pre-integration complex (en)
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| - El complejo de preintegración (PIC, del inglés pre-integration complex) es un complejo de nucleoproteínas de material genético viral y proteínas virales y del huésped asociadas que es capaz de insertar un genoma viral en un genoma del huésped. El PIC se forma después de destapar una partícula viral después de entrar en la célula huésped. En el caso del virus de la inmunodeficiencia humana (VIH), el PIC se forma después de que el complejo de transcripción inversa (RTC, del inglés Reverse Transcription Complex) haya transcrito de forma inversa el ARN viral en ADN. El PIC consta de proteínas virales (incluidas , e integrasa), proteínas del huésped (incluida la ) y el ADN viral. El PIC ingresa al núcleo celular a través del complejo de poro nuclear sin romper la envoltura nuclear, lo que per (es)
- The pre-integration complex (PIC) is a nucleoprotein complex of viral genetic material and associated viral and host proteins which is capable of inserting a viral genome into a host genome. The PIC forms after uncoating of a viral particle after entry into the host cell. In the case of the human immunodeficiency virus (HIV), the PIC forms after the Reverse Transcription Complex (RTC) has reverse transcribed the viral RNA into DNA. The PIC consists of viral proteins (including Vpr, matrix and integrase), host proteins (including Barrier to autointegration factor 1) and the viral DNA. The PIC enters the cellular nucleus through the nuclear pore complex without disrupting the nuclear envelope, thus allowing HIV and related retroviruses to replicate in non-dividing cells. Following nuclear en (en)
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| - El complejo de preintegración (PIC, del inglés pre-integration complex) es un complejo de nucleoproteínas de material genético viral y proteínas virales y del huésped asociadas que es capaz de insertar un genoma viral en un genoma del huésped. El PIC se forma después de destapar una partícula viral después de entrar en la célula huésped. En el caso del virus de la inmunodeficiencia humana (VIH), el PIC se forma después de que el complejo de transcripción inversa (RTC, del inglés Reverse Transcription Complex) haya transcrito de forma inversa el ARN viral en ADN. El PIC consta de proteínas virales (incluidas , e integrasa), proteínas del huésped (incluida la ) y el ADN viral. El PIC ingresa al núcleo celular a través del complejo de poro nuclear sin romper la envoltura nuclear, lo que permite que el VIH y los retrovirus relacionados se repliquen en células que no se dividen. Después de la entrada nuclear, la carga útil de ADN del PIC puede integrarse en el ADN del huésped como un "provirus". (es)
- The pre-integration complex (PIC) is a nucleoprotein complex of viral genetic material and associated viral and host proteins which is capable of inserting a viral genome into a host genome. The PIC forms after uncoating of a viral particle after entry into the host cell. In the case of the human immunodeficiency virus (HIV), the PIC forms after the Reverse Transcription Complex (RTC) has reverse transcribed the viral RNA into DNA. The PIC consists of viral proteins (including Vpr, matrix and integrase), host proteins (including Barrier to autointegration factor 1) and the viral DNA. The PIC enters the cellular nucleus through the nuclear pore complex without disrupting the nuclear envelope, thus allowing HIV and related retroviruses to replicate in non-dividing cells. Following nuclear entry, the PIC's DNA payload may be integrated into the host DNA as a "provirus". (en)
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