About: Pre-replication complex

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A pre-replication complex (pre-RC) is a protein complex that forms at the origin of replication during the initiation step of DNA replication. Formation of the pre-RC is required for DNA replication to occur. Complete and faithful replication of the genome ensures that each daughter cell will carry the same genetic information as the parent cell. Accordingly, formation of the pre-RC is a very important part of the cell cycle.

Attributes	Values
rdf:type	yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteins
rdfs:label	Complesso di pre-replicazione (it) 複製前複合体 (ja) Pre-replication complex (en) Пререпликационный комплекс (ru)
rdfs:comment	A pre-replication complex (pre-RC) is a protein complex that forms at the origin of replication during the initiation step of DNA replication. Formation of the pre-RC is required for DNA replication to occur. Complete and faithful replication of the genome ensures that each daughter cell will carry the same genetic information as the parent cell. Accordingly, formation of the pre-RC is a very important part of the cell cycle. (en) 複製前複合体または複製開始前複合体（ふくせい(かいし)まえふくごうたい、英: pre-replication complex、略称: pre-RC）は、DNA複製の開始段階に複製起点に形成されるタンパク質複合体である。pre-RCの形成はDNA複製が起こるために必要である。ゲノムの完全に忠実に複製されることによって、各娘細胞が親細胞と同一の遺伝情報を持つことが保証される。したがって、pre-RCの形成は細胞周期の非常に重要な部分をなしている。 (ja) Пререпликацио́нный ко́мплекс (англ. pre-replication complex, pre-RC) — комплекс белков, который образуется на стадии инициации репликации ДНК. Белки, которые принимают участие в пререпликационном комплексе, строго необходимы для репликации. (ru) Il complesso di pre-replicazione (in inglese pre-Replication Complex, o pre-RC) è un complesso multiproteico che nelle cellule eucariote si assembla sulle origini di replicazione del DNA il cui ruolo è quello di iniziare la replicazione del DNA. (it)
foaf:depiction
dcterms:subject	DNA replication
Wikipage page ID	619178 (xsd:integer)
Wikipage revision ID	1108420759 (xsd:integer)
Link from a Wikipage to another Wikipage	Caenorhabditis elegans Proteasome ORC1 Cyclin-dependent kinase DNA polymerase DNA re-replication DNA replication CDC45-related protein CDC6 Saccharomyces cerevisiae Geminin Genome Origin of replication Origin recognition complex Mammals Schizosaccharomyces pombe Bacteria Cdc6 DnaA DnaB helicase DnaC DnaG Drosophila melanogaster G1 phase ORC6 Dwarfism Eukaryotic Cell cycle Cell proliferation Chromatin Protein complex DNA replication Primase Metazoans Microcephaly Minichromosome maintenance OriC Xenopus laevis Single-strand binding protein ORC4 MCM10 Phosphorylation Replisome Hypoplastic Archaeal Cdt1 Patellae CDC7 M phase dbr:Meier-Gorlin_syndrome
sameAs	Pre-replication complex Pre-replication complex Pre-replication complex Pre-replication complex Pre-replication complex Pre-replication complex Pre-replication complex Pre-replication complex Pre-replication complex
dbp:wikiPageUsesTemplate	dbt:Refimprove dbt:Reflist dbt:DNA_replication
thumbnail	wiki-commons:Special:FilePath/EukPreRC.jpg?width=300
has abstract	A pre-replication complex (pre-RC) is a protein complex that forms at the origin of replication during the initiation step of DNA replication. Formation of the pre-RC is required for DNA replication to occur. Complete and faithful replication of the genome ensures that each daughter cell will carry the same genetic information as the parent cell. Accordingly, formation of the pre-RC is a very important part of the cell cycle. (en) Il complesso di pre-replicazione (in inglese pre-Replication Complex, o pre-RC) è un complesso multiproteico che nelle cellule eucariote si assembla sulle origini di replicazione del DNA il cui ruolo è quello di iniziare la replicazione del DNA. L'assemblaggio del complesso sulle origini di replicazione avviene durante la fase M tardiva e prosegue nella fase G1 precoce del ciclo cellulare, quando i livelli delle cicline sono bassi. Il livello basso di cicline consente infatti la formazione del pre-RC ma non ne permette l'attivazione, che richiede invece alti livelli di cicline E ed A: questo è uno dei più importanti meccanismi che impedisce la doppia replicazione di una stessa regione di DNA all'interno di un solo ciclo. La regolazione dell'assemblaggio del pre-RC è dunque il processo fondamentale che fa sì che durante la replicazione cellulare non vengano lasciate regioni di DNA non replicate o che altre regioni vengano replicate più di una volta. (it) 複製前複合体または複製開始前複合体（ふくせい(かいし)まえふくごうたい、英: pre-replication complex、略称: pre-RC）は、DNA複製の開始段階に複製起点に形成されるタンパク質複合体である。pre-RCの形成はDNA複製が起こるために必要である。ゲノムの完全に忠実に複製されることによって、各娘細胞が親細胞と同一の遺伝情報を持つことが保証される。したがって、pre-RCの形成は細胞周期の非常に重要な部分をなしている。 (ja) Пререпликацио́нный ко́мплекс (англ. pre-replication complex, pre-RC) — комплекс белков, который образуется на стадии инициации репликации ДНК. Белки, которые принимают участие в пререпликационном комплексе, строго необходимы для репликации. (ru)
gold:hypernym	Protein

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