Prescott Metcalf (January 25, 1813 – October 14, 1891) was a prominent businessman and the 8th mayor of Erie, Pennsylvania. He was one of the first Republican mayors of Erie, Pennsylvania, a post he held from 1862 to 1864. His children were Joseph P. Metcalf, (1847–1901); Windham Wilder Metcalf, (1847–1851); Frederick Wilder Metcalf, (d. 1890); Nellie Metcalf, (d. 1856); and George Ralph Metcalf, (1858–1931). One of thirteen children, Metcalf was born in Putney, Vermont. He arrived in Erie in 1835.