About: Protein phosphatase 2

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Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. Its serine/threonine phosphatase activity has a broad substrate specificity and diverse cellular functions. Among the targets of PP2A are proteins of oncogenic signaling cascades, such as Raf, MEK, and AKT, where PP2A may act as a tumor suppressor.

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rdf:type	Thing Biomolecule Biomolecule Protein yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 yago:WikicatHumanProteins protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459
rdfs:label	Protéine phosphatase 2 (fr) プロテインホスファターゼ2 (ja) Protein phosphatase 2 (en) Фосфатаза 2 (ru) 蛋白磷酸酶2 (zh)
rdfs:comment	Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. Its serine/threonine phosphatase activity has a broad substrate specificity and diverse cellular functions. Among the targets of PP2A are proteins of oncogenic signaling cascades, such as Raf, MEK, and AKT, where PP2A may act as a tumor suppressor. (en) プロテインホスファターゼ2 (protein phosphatase 2, PP2) は、普遍的に発現しているヘテロ三量体型プロテインホスファターゼで、PP2Aとしても知られる。真核生物細胞におけるホスファターゼ活性の大部分を担う。そのセリン/スレオニンホスファターゼ活性は広い基質特異性を持ち、多様な細胞機能に関与する。PP2Aの標的にはRaf、MEK、AKTといった発がん性シグナル伝達カスケードのタンパク質が含まれ、PP2Aはがん抑制因子として機能する。 (ja) Белок фосфатазы 2 (PP2) (англ. Protein phosphatase 2), также известный как PP2A — фермент, кодируемый у человека геном PPP2CA. PP2A — гетеротримерная протеинфосфатаза, являющаяся убиквитарной и консервативной серин/треонин фосфатазой с широкой субстратной специфичностью и разнообразными клеточными функциями. Целями PP2A являются белки онкогенных сигнальных каскадов, такие как , , и AKT. (ru) 蛋白磷酸酶2（英語：Protein phosphatase 2，簡稱PP2或PP2A）是由PPP2CA基因编码的蛋白磷酸酶。PP2A存在于很多组织中，為异三聚体，屬於丝氨酸/苏氨酸磷酸酶，具有广泛的底物特异性和多样的细胞功能。PP2A的底物都是信号传导级联反应中的癌蛋白，如AKT、和。 (zh) La protéine phosphatase 2 (PP2), également appelée PP2A, est une enzyme qui, chez l'homme, est codée par les gènes PPP2CA (isoforme α) et PPP2CB (isoforme β) situés sur le chromosome 5 et le chromosome 8 respectivement. Il s'agit d'une protéine hétérotrimérique exprimée de manière ubiquitaire qui assure une partie importante de l'activité phosphatase dans les cellules d'eucaryotes. Son activité phosphatase est caractérisée par une large spécificité de substrats et une grande diversité de fonctions cellulaires. Parmi les cibles de la protéine phosphatase 2, on compte notamment les protéines des cascades de signalisation oncogène comme c-Raf, (en) et Akt1, vis-à-vis desquelles elle agit comme suppresseur de tumeur. (fr)
foaf:name	protein phosphatase 2, catalytic subunit, beta isoform (en) protein phosphatase 2, catalytic subunit, alpha isoform (en)
name	PPP2CB PPP2CA
foaf:depiction
dcterms:subject	EC 3.1.3 Human proteins
Wikipage page ID	20177401 (xsd:integer)
Wikipage revision ID	1093250267 (xsd:integer)
Link from a Wikipage to another Wikipage	Protein phosphatase Protein serine/threonine phosphatase PPP2R3C Tumors of the hematopoietic and lymphoid tissues EC 3.1.3 Human proteins PPP2R5A PPP2R5D PPP2R2B Enzyme Gene Leucine Manganese Tumor suppressor gene Microcystin Active site PPP2CB Alzheimer's disease Eukaryote Parkinson's disease PPP2R2C Biological target Heterotrimeric G protein dbr:C-Raf C-terminus HEAT repeat domain Methylated Mitogen-activated protein kinase kinase PPP2R2A PPP2R5B PPP2R5E Rubratoxin PPP2R1A N-terminus PPP2R3B PPP2R3A AKT PPP2R4 PPP2CA PPP2R2D PPP2R5C PPP2R1B Carboxyl group
sameAs	Protein phosphatase 2 Protein phosphatase 2 Protein phosphatase 2 Protein phosphatase 2 Protein phosphatase 2 Protein phosphatase 2 Protein phosphatase 2 Protein phosphatase 2 Protein phosphatase 2 Protein phosphatase 2 Protein phosphatase 2
dbp:wikiPageUsesTemplate	dbt:Cite_journal dbt:Enzymes dbt:Esterases dbt:MeshName

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