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Pyrazolam (SH-I-04) is a benzodiazepine derivative originally developed by a team led by Leo Sternbach at Hoffman-La Roche in the 1970s. It has since been "rediscovered" and sold as a designer drug since 2012. Pyrazolam has structural similarities to alprazolam and bromazepam. Unlike other benzodiazepines, pyrazolam does not appear to undergo metabolism, instead being excreted unchanged in the urine. It is most selective for the α2 and α3 subtypes of the GABAA receptor.

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rdf:type
rdfs:label
  • Pyrazolam (de)
  • Pyrazolam (fr)
  • Pirazolam (it)
  • Pyrazolam (en)
  • Pirazolam (pt)
rdfs:comment
  • Pyrazolam ist eine chemische Verbindung aus der Gruppe der Benzodiazepine. Pyrazolam weist strukturelle Ähnlichkeiten mit Alprazolam und Bromazepam auf. Es ist sehr selektiv für die α2- und α3-Rezeptor-Subtypen, das heißt, es wirkt stark angstlösend. Es wird unverändert im Urin ausgeschieden. Pyrazolam wurde erstmals 1970 von der Arbeitsgruppe um Leo Sternbach bei Hoffmann-La Roche synthetisiert. Seit 2012 wird Pyrazolam als Forschungschemikalie und Designerdroge verwendet. (de)
  • Pyrazolam (SH-I-04) is a benzodiazepine derivative originally developed by a team led by Leo Sternbach at Hoffman-La Roche in the 1970s. It has since been "rediscovered" and sold as a designer drug since 2012. Pyrazolam has structural similarities to alprazolam and bromazepam. Unlike other benzodiazepines, pyrazolam does not appear to undergo metabolism, instead being excreted unchanged in the urine. It is most selective for the α2 and α3 subtypes of the GABAA receptor. (en)
  • Le pyrazolam est une benzodiazépine développée par une équipe dirigée par Leo Sternbach, travaillant pour Hoffman-La Roche dans les années 1970. Elle n'a cependant jamais été utilisé dans l'industrie pharmaceutique. Elle a refait surface sur internet en tant que research chemical en 2012. Comme la plupart des benzodiazepines elle possède des effets anxiolytiques, sédatives, myorelaxantes, anticonvulsivantes et amnésiques. (fr)
  • Il pirazolam è uno psicofarmaco appartenente alla categoria delle benzodiazepine originariamente sviluppato da un team guidato da Leo Sternbach a Hoffman-La Roche negli anni 70'. Da allora è stato "riscoperto" e venduto come designer drug dal 2012. Il pirazolam ha varie somiglianze strutturali con alprazolam e bromazepam. A differenza di altre benzodiazepine, il pirazolam non sembra essere metabolizzato, ma viene espulso tramite urina. È più selettivo per i recettori GABA A α2 e 3. (it)
  • Pirazolam (SH-I-04) é um derivado benzodiazepínico originalmente desenvolvido por uma equipe liderada por Leo Sternbach na Hoffman-La Roche na década de 1970, e subsequentemente "redescoberto" e vendido como droga artificial a partir de 2012. O pirazolam tem semelhanças estruturais com o alprazolam e o bromazepam. Ao contrário de outros benzodiazepínicos, o pirazolam não parece sofrer metabolismo, sendo excretado inalterado na urina. É mais seletivo para os subtipos α2 e α3 do receptor GABAA. (pt)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/Pyrazolam-skeletal.svg
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legal DE
  • NpSG (en)
legal UK
  • Class C (en)
legal US
  • Unscheduled (en)
n
PubChem
routes of administration
SMILES
  • CC1=NN=C2CN=CC3=CC=CC=C3N12 (en)
StdInChI
StdInChIKey
  • BGRWSFIQQPVEML-UHFFFAOYSA-N (en)
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has abstract
  • Pyrazolam ist eine chemische Verbindung aus der Gruppe der Benzodiazepine. Pyrazolam weist strukturelle Ähnlichkeiten mit Alprazolam und Bromazepam auf. Es ist sehr selektiv für die α2- und α3-Rezeptor-Subtypen, das heißt, es wirkt stark angstlösend. Es wird unverändert im Urin ausgeschieden. Pyrazolam wurde erstmals 1970 von der Arbeitsgruppe um Leo Sternbach bei Hoffmann-La Roche synthetisiert. Seit 2012 wird Pyrazolam als Forschungschemikalie und Designerdroge verwendet. (de)
  • Pyrazolam (SH-I-04) is a benzodiazepine derivative originally developed by a team led by Leo Sternbach at Hoffman-La Roche in the 1970s. It has since been "rediscovered" and sold as a designer drug since 2012. Pyrazolam has structural similarities to alprazolam and bromazepam. Unlike other benzodiazepines, pyrazolam does not appear to undergo metabolism, instead being excreted unchanged in the urine. It is most selective for the α2 and α3 subtypes of the GABAA receptor. (en)
  • Le pyrazolam est une benzodiazépine développée par une équipe dirigée par Leo Sternbach, travaillant pour Hoffman-La Roche dans les années 1970. Elle n'a cependant jamais été utilisé dans l'industrie pharmaceutique. Elle a refait surface sur internet en tant que research chemical en 2012. Comme la plupart des benzodiazepines elle possède des effets anxiolytiques, sédatives, myorelaxantes, anticonvulsivantes et amnésiques. (fr)
  • Il pirazolam è uno psicofarmaco appartenente alla categoria delle benzodiazepine originariamente sviluppato da un team guidato da Leo Sternbach a Hoffman-La Roche negli anni 70'. Da allora è stato "riscoperto" e venduto come designer drug dal 2012. Il pirazolam ha varie somiglianze strutturali con alprazolam e bromazepam. A differenza di altre benzodiazepine, il pirazolam non sembra essere metabolizzato, ma viene espulso tramite urina. È più selettivo per i recettori GABA A α2 e 3. (it)
  • Pirazolam (SH-I-04) é um derivado benzodiazepínico originalmente desenvolvido por uma equipe liderada por Leo Sternbach na Hoffman-La Roche na década de 1970, e subsequentemente "redescoberto" e vendido como droga artificial a partir de 2012. O pirazolam tem semelhanças estruturais com o alprazolam e o bromazepam. Ao contrário de outros benzodiazepínicos, o pirazolam não parece sofrer metabolismo, sendo excretado inalterado na urina. É mais seletivo para os subtipos α2 e α3 do receptor GABAA. (pt)
legal AU
  • S4 (en)
legal CA
  • Schedule IV (en)
prov:wasDerivedFrom
page length (characters) of wiki page
CAS number
  • 39243-02-2
ChEMBL
  • 3246831
FDA UNII code
  • 8LH16383PK
PubChem
  • 12562545
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