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About: RIG-I-like receptor     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatRIG-I-likeReceptors, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: yago:BodyPart105220461yago:Part109385911yago:PhysicalEntity100001930yago:Receptor105608868yago:WikicatIntracellularReceptorsproteinyago:Structure105225602yago:Thing100002452yago:WikicatRIG-I-likeReceptors New Facet based on Instances of this Class

RIG-like receptors (retinoic acid-inducible gene-I-like receptors, RLRs) are a type of intracellular pattern recognition receptor involved in the recognition of viruses by the innate immune system. RIG-I (retinoic-acid inducible gene or DDX58) is the best characterized receptor within the RIG-I like receptor (RLR) family. Together with MDA5 (melanoma differentiation-associated 5) and LGP2 (laboratory of genetics and physiology 2), this family of cytoplasmic pattern recognition receptors (PRRs) are sentinels for intracellular viral RNA that is a product of viral infection. The RLR receptors provide frontline defence against viral infections in most tissues.