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The Rab family of proteins is a member of the Ras superfamily of small G proteins. Approximately 70 types of Rabs have now been identified in humans. Rab proteins generally possess a GTPase fold, which consists of a six-stranded beta sheet which is flanked by five alpha helices. Rab GTPases regulate many steps of membrane trafficking, including vesicle formation, vesicle movement along actin and tubulin networks, and membrane fusion. These processes make up the route through which cell surface proteins are trafficked from the Golgi to the plasma membrane and are recycled. Surface protein recycling returns proteins to the surface whose function involves carrying another protein or substance inside the cell, such as the transferrin receptor, or serves as a means of regulating the number of a

AttributesValues
rdf:type
rdfs:label
  • Proteïna Rab (ca)
  • Rab (protein) (cs)
  • Rab-Proteine (de)
  • Rab (proteína) (es)
  • Rab (proteina) (it)
  • Rab (protéine G) (fr)
  • Rab (G-protein) (en)
  • Rab (proteína) (pt)
rdfs:comment
  • Rab je rodina proteinů, jež se řadí do nadrodiny Ras monomerických G proteinů. U člověka bylo dosud identifikováno kolem 45 různých typů těchto proteinů. Vyskytují se však u všech eukaryotických organismů a pravděpodobně i u archebakterií. Rab GTPázy regulují mnoho kroků membránové přepravy včetně tvorby váčků, jejich pohybu po aktinových a tubulinových vláknech a splývání membrán. Umožňují, aby váčky putovaly buňkou přesně na místo svého určení. (cs)
  • Die Familie der Rab-Proteine („Ras-related in brain“) gehört zur Ras-Superfamilie monomerer G-Proteine (GTPasen) und ist in Eukaryoten zu großen Teilen konserviert.Bei Menschen gibt es über 60 bekannte Rab-Proteine, die jeweils eine spezifische subzelluläre Lokalisation aufweisen und eine Rolle bei der intrazellulären Vesikelsortierung zwischen den verschiedenen Kompartimenten spielen. Allgemein wird eine aktive Form, in der GTP gebunden ist und eine inaktive, GDP-haltige Form unterschieden. (de)
  • As Rabs constituem uma família de proteínas de reconhecimento e endereçamento com função GTPase que, juntamente com outras proteínas, fazem parte do sistema de transporte e de reconhecimento de vesículas e certas organelas em células eucarióticas, controlando o ancoramento (docking) dos compartimentos envolvidos (membrana do compartimento transportado à do compartimento alvo), ou seja, assegurando que a membrana do compartimento em questão se aloque no sítio ativo correto através do qual será incorporada via fusão de membranas mediada por SNARE. Muitas vesículas transportadoras só se formam se um tipo específico de proteína Rab e SNARE estiverem acopladas a sua membrana, permitindo assim que a vesícula funda corretamente sua membrana com a do seu alvo. (pt)
  • Les Rab són unes molècules que pertanyen a la família de les proteïnes G i que intervenen en el . Les proteïnes Rab són unes petites proteïnes de la família de les proteïnes GTP-ases involucrades de manera essencial en aquest procés. La seva funció consisteix a regular el transport entre orgànuls assegurant l'especificitat d'aquest procés. (ca)
  • Las Rab son una familia de proteínas GTPasas de la superfamilia Ras. Forman parte del sistema de formación y transporte de vesículas y fusión de membranas, controlando el reconocimiento inicial o anclaje de las vesículas a la membrana del compartimiento celular al que deben incorporarse.​ Existen numerosas isoformas de Rab en las membranas de diferentes compartimentos celulares.​ (es)
  • The Rab family of proteins is a member of the Ras superfamily of small G proteins. Approximately 70 types of Rabs have now been identified in humans. Rab proteins generally possess a GTPase fold, which consists of a six-stranded beta sheet which is flanked by five alpha helices. Rab GTPases regulate many steps of membrane trafficking, including vesicle formation, vesicle movement along actin and tubulin networks, and membrane fusion. These processes make up the route through which cell surface proteins are trafficked from the Golgi to the plasma membrane and are recycled. Surface protein recycling returns proteins to the surface whose function involves carrying another protein or substance inside the cell, such as the transferrin receptor, or serves as a means of regulating the number of a (en)
  • La famille de protéines Rab est membre de la superfamille Ras des petites protéines G . Environ 70 types de Rabs ont maintenant été identifiés chez l'homme. Les protéines Rab possèdent généralement un repli GTPase, qui consiste en une feuille bêta à six brins qui est flanquée de cinq hélices alpha . Les GTPases Rab régulent de nombreuses étapes du trafic membranaire, y compris la formation de vésicules, le mouvement des vésicules le long des réseaux d' actine et de tubuline et la fusion membranaire. Ces processus constituent la voie par laquelle les protéines de surface cellulaire sont acheminées du Golgi vers la membrane plasmique et sont recyclées. Le recyclage des protéines de surface renvoie des protéines à la surface dont la fonction implique le transport d'une autre protéine ou subst (fr)
  • Le proteine Rab sono GTPasi monomeriche coinvolte nel . Come tutte le GTP-asi, sono attive se legate a GTP e inattive se legate a GDP; quando sono inattive sono legate a una proteina inibitrice detta GDI che le mantiene solubili nel citosol. I complessi attivano le Rab inattive scambiando GDP con GTP. Una volta attivate, le Rab si legano alla membrana di un organulo o a una vescicola di trasporto e si legano agli effettori rab. Affinché possano svolgere la loro funzione, le proteine rab devono essere attivate sia nella che nella membrana di attracco. Sono stati scoperti finora 60 tipi di Rab. (it)
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