Ralph Benedict D'Agostino Sr. (born August 16, 1940) is an American biostatistician and professor of Mathematics/Statistics, Biostatistics and Epidemiology at Boston University. He is also the director of the Statistics and Consulting Unit of the Framingham Study and the executive director of the M.A./Ph.D. program in biostatistics at Boston University. He was elected a fellow of the American Statistical Association in 1990 and of the American Heart Association in 1991.