Ramón de los Santos Genero (January 19, 1949 – November 29, 2015) was a Dominican Major League Baseball relief pitcher and scout. The left-hander signed as a free agent with the Houston Astros on April 9, 1972 and played for them in 1974. De los Santos was called up to Houston in August 1974 after a season dominating hitters in the Double-A Southern League. Pitching in 42 games for the Columbus Astros, he struck out 73 batters in 76 innings and allowed only 11 earned runs. He was 7–4 with an ERA of 1.30.