Reginald Beseley was one of two Members of the Parliament of England for the borough of Scarborough in 1545, 1547, the November session of 1554 and in 1559. He also represented the borough of Thirsk in the March session of 1553 and the April session of 1554, as well as the borough of Knaresborough in the October session of 1553 and also the constituency of York in 1555.