SK-OV-3 (also known as SKOV-3; SK.OV.3; SKOV3; Skov3 and SKO3) is an ovarian cancer cell line derived from the ascites of a 64-year-old Caucasian female with an ovarian serous cystadenocarcinoma. The SK-OV-3 cell line is also hypodiploid, with a modal number of chromosomes of 43 (range 42-45), occurring in 63.3% of cells. SK-OV-3 are positive for many of the antigens used to identify cancers of epithelial origin in clinical practice, including vimentin (VIM), high molecular weight cytokeratin (HMWK), low molecular weight cytokeratin (LMWK), epithelial membrane antigen (EMA) and leucocyte common antigen (LCA).
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| - SK-OV-3 (en)
- SK-OV-3 (zh)
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| - SK-OV-3 (also known as SKOV-3; SK.OV.3; SKOV3; Skov3 and SKO3) is an ovarian cancer cell line derived from the ascites of a 64-year-old Caucasian female with an ovarian serous cystadenocarcinoma. The SK-OV-3 cell line is also hypodiploid, with a modal number of chromosomes of 43 (range 42-45), occurring in 63.3% of cells. SK-OV-3 are positive for many of the antigens used to identify cancers of epithelial origin in clinical practice, including vimentin (VIM), high molecular weight cytokeratin (HMWK), low molecular weight cytokeratin (LMWK), epithelial membrane antigen (EMA) and leucocyte common antigen (LCA). (en)
- SK-OV-3是一種二倍體卵巢癌細胞系,最初在1973年分離自一名64歲白人女性囊腺癌患者的腹水。在63.3%的SK-OV-3細胞中,染色體的模態數為43,而範圍則為42至45。 SK-OV-3對許多用於鑑定上皮來源癌的抗原,呈陽性反應,包括波形蛋白、高分子量、低分子量細胞角蛋白、上皮膜抗原(epithelial membrane antigen)和蛋白酪氨酸磷酸酶C型受體。早期的研究報告指出,SK-OV-3細胞不會表達CA-125(一種細胞表面抗原),而該抗原後來成為檢測卵巢癌最常用的生物標誌物,並且通過表明SK-OV-3細胞對鉑敏感。隨後的研究更顯示,SK-OV-3細胞中CA-125 C末端結構域的異位表達,降低了其對順鉑誘導的細胞凋亡的敏感性。目前已經有研究指出其具有中度分化能力,將SK-OV-3注入裸鼠後,裸鼠體內會產生大的實體腫瘤,並且會鬆散地附著在骨盆區域、腸或的脂肪上。 (zh)
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| - SK-OV-3 (also known as SKOV-3; SK.OV.3; SKOV3; Skov3 and SKO3) is an ovarian cancer cell line derived from the ascites of a 64-year-old Caucasian female with an ovarian serous cystadenocarcinoma. The SK-OV-3 cell line is also hypodiploid, with a modal number of chromosomes of 43 (range 42-45), occurring in 63.3% of cells. SK-OV-3 are positive for many of the antigens used to identify cancers of epithelial origin in clinical practice, including vimentin (VIM), high molecular weight cytokeratin (HMWK), low molecular weight cytokeratin (LMWK), epithelial membrane antigen (EMA) and leucocyte common antigen (LCA). (en)
- SK-OV-3是一種二倍體卵巢癌細胞系,最初在1973年分離自一名64歲白人女性囊腺癌患者的腹水。在63.3%的SK-OV-3細胞中,染色體的模態數為43,而範圍則為42至45。 SK-OV-3對許多用於鑑定上皮來源癌的抗原,呈陽性反應,包括波形蛋白、高分子量、低分子量細胞角蛋白、上皮膜抗原(epithelial membrane antigen)和蛋白酪氨酸磷酸酶C型受體。早期的研究報告指出,SK-OV-3細胞不會表達CA-125(一種細胞表面抗原),而該抗原後來成為檢測卵巢癌最常用的生物標誌物,並且通過表明SK-OV-3細胞對鉑敏感。隨後的研究更顯示,SK-OV-3細胞中CA-125 C末端結構域的異位表達,降低了其對順鉑誘導的細胞凋亡的敏感性。目前已經有研究指出其具有中度分化能力,將SK-OV-3注入裸鼠後,裸鼠體內會產生大的實體腫瘤,並且會鬆散地附著在骨盆區域、腸或的脂肪上。 (zh)
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