SM UC-65 was a German Type UC II minelaying submarine or U-boat in the German Imperial Navy (German: Kaiserliche Marine) during World War I. The U-boat was ordered on 12 January 1916 and was launched on 8 July 1916. She was commissioned into the German Imperial Navy on 7 November 1916 as SM UC-65. In eleven patrols UC-65 was credited with sinking 106 ships, either by torpedo or by mines laid. UC-65 was torpedoed and sunk by HMS C15 on 3 November 1917.