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SX-3228 is a sedative and hypnotic drug used in scientific research. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic. SX-3228 is a subtype-selective GABAA positive allosteric modulator acting primarily at the α1 subtype. It thus has similar effects to other α1-selective drugs such as zolpidem and zaleplon in animal studies. It only partly substitutes for ethanol, and is a strong sedative-hypnotic with only limited anxiolytic effects which appear only at doses that also produce significant sedation.

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  • SX-3228 (en)
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  • SX-3228 is a sedative and hypnotic drug used in scientific research. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic. SX-3228 is a subtype-selective GABAA positive allosteric modulator acting primarily at the α1 subtype. It thus has similar effects to other α1-selective drugs such as zolpidem and zaleplon in animal studies. It only partly substitutes for ethanol, and is a strong sedative-hypnotic with only limited anxiolytic effects which appear only at doses that also produce significant sedation. (en)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/SX-3228.svg
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SMILES
  • COc1nncC/3=C/C=4CNCCC=4NC\3=O (en)
StdInChI
StdInChIKey
  • BZLLVTYOOJNQIF-UHFFFAOYSA-N (en)
synonyms
  • (5,6,7,8-tetrahydro-3--6--1,6-naphthyridin-2-one) (en)
UNII
  • A5XC39S5SP (en)
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  • changed (en)
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  • SX-3228 is a sedative and hypnotic drug used in scientific research. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic. SX-3228 is a subtype-selective GABAA positive allosteric modulator acting primarily at the α1 subtype. It thus has similar effects to other α1-selective drugs such as zolpidem and zaleplon in animal studies. It only partly substitutes for ethanol, and is a strong sedative-hypnotic with only limited anxiolytic effects which appear only at doses that also produce significant sedation. (en)
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CAS number
  • 156364-04-4
FDA UNII code
  • A5XC39S5SP
PubChem
  • 5487538
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