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SaPIs (Staphylococcus aureus pathogenicity islands) are a family of ~15 kb mobile genetic elements resident in the genomes of the vast majority of S. aureus strains. Much like bacteriophages, SaPIs can be transferred to uninfected cells and integrate into the host chromosome. Unlike the bacterial viruses, however, integrated SaPIs are mobilized by host infection with "helper" bacteriophages (specific SaPIs may require specific helper bacteriophages for mobilization, though Staphylococcus phage 80alpha appears to mobilize all known SaPIs). SaPIs are used by the host bacteria to co-opt the phage reproduction cycle for their own genetic transduction and also inhibit phage reproduction in the process.

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  • ブドウ球菌病原性遺伝子島 (ja)
  • SaPI (en)
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  • ブドウ球菌病原性遺伝子島あるいはSaPI(Staphylococcus aureus pathogenicity islands)とは黄色ブドウ球菌の多くの株のゲノムに存在する可動遺伝因子のファミリーの一つである。SaPIは複数のSE遺伝子およびSEI遺伝子をコードする。例えばSaPI1はsekとseqを、SaPI3はseb、sek、seqを、SaPIbov1はsec、selをコードする。異なるSaPIは異なる毒素遺伝子パターンを保有する。一方、同じ毒素遺伝子が異なるSaPIにコードされることもある。バクテリオファージのように、SaPIは非感染細胞に移入して宿主の染色体に自身を組み込まさせることができる。ただし、細菌ウイルスとは異なり、組み込まれたSaPIはによる宿主への感染によって動員される(特定のSaPIは、動員に特異的なヘルパーファージを要求することもあるが、ブドウ球菌ファージ80alphaは全ての既知SaPIを動員することができるようである)。 (ja)
  • SaPIs (Staphylococcus aureus pathogenicity islands) are a family of ~15 kb mobile genetic elements resident in the genomes of the vast majority of S. aureus strains. Much like bacteriophages, SaPIs can be transferred to uninfected cells and integrate into the host chromosome. Unlike the bacterial viruses, however, integrated SaPIs are mobilized by host infection with "helper" bacteriophages (specific SaPIs may require specific helper bacteriophages for mobilization, though Staphylococcus phage 80alpha appears to mobilize all known SaPIs). SaPIs are used by the host bacteria to co-opt the phage reproduction cycle for their own genetic transduction and also inhibit phage reproduction in the process. (en)
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  • SaPIs (Staphylococcus aureus pathogenicity islands) are a family of ~15 kb mobile genetic elements resident in the genomes of the vast majority of S. aureus strains. Much like bacteriophages, SaPIs can be transferred to uninfected cells and integrate into the host chromosome. Unlike the bacterial viruses, however, integrated SaPIs are mobilized by host infection with "helper" bacteriophages (specific SaPIs may require specific helper bacteriophages for mobilization, though Staphylococcus phage 80alpha appears to mobilize all known SaPIs). SaPIs are used by the host bacteria to co-opt the phage reproduction cycle for their own genetic transduction and also inhibit phage reproduction in the process. SaPIs can infect many strains that are resistant to phages, and can readily be transferred to Listeria monocytogenes even though staphylococcal phages cannot grow in Listeria cells. SaPIs occur infrequently in other staphylococcal species, but SaPI-like elements are common and widespread in other Gram-positive cocci. (en)
  • ブドウ球菌病原性遺伝子島あるいはSaPI(Staphylococcus aureus pathogenicity islands)とは黄色ブドウ球菌の多くの株のゲノムに存在する可動遺伝因子のファミリーの一つである。SaPIは複数のSE遺伝子およびSEI遺伝子をコードする。例えばSaPI1はsekとseqを、SaPI3はseb、sek、seqを、SaPIbov1はsec、selをコードする。異なるSaPIは異なる毒素遺伝子パターンを保有する。一方、同じ毒素遺伝子が異なるSaPIにコードされることもある。バクテリオファージのように、SaPIは非感染細胞に移入して宿主の染色体に自身を組み込まさせることができる。ただし、細菌ウイルスとは異なり、組み込まれたSaPIはによる宿主への感染によって動員される(特定のSaPIは、動員に特異的なヘルパーファージを要求することもあるが、ブドウ球菌ファージ80alphaは全ての既知SaPIを動員することができるようである)。 (ja)
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