Samuel Vassall (baptised 1586 – 1667) was an English merchant, politician, and slave trader who sat in the House of Commons from 1640 to 1648. Vassall financed slave ships in the 1640s and was the majority shareholder of the Guinea Company, founded in 1651 to transport enslaved Africans to European colonies in the Americas. Samuel Vassall was 77 when he left London for Carolina in 1663. He died in the America colonies in 1667.