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Saos-2 ("Sarcoma osteogenic") is a cell line derived from the primary osteosarcoma of an 11-year-old Caucasian girl in 1973 by Fogh et al. The cell line is commonly used in bone cancer research as a model for testing novel therapies. In 1987 Rodan et al. determined that Saos-2 cells "possess several osteoblastic features and could be useful as a permanent line of human osteoblast-like cells and as a source of bone-related molecules."

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  • Cèl·lules SaOS-2 (ca)
  • Saos-2 cells (en)
  • Saos-2 (zh)
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  • Saos-2是一種人類骨肉瘤細胞系,通常在骨癌研究中用作研究新療法的模型,最初是在1973年分離自一名11歲白人女性原發性骨肉瘤中患者,而該患者已接受氨甲蝶呤、阿黴素及長春新鹼等的治療。 1987年,科研人員發現細胞對副甲狀腺激素顯示敏感的腺苷酸環化酶反應,隨細胞密度增加而增加,並且通過地塞米松(一種人工合成的皮質類固醇)治療進一步提高。隨後確定Saos-2細胞具有數個成骨細胞的特徵,故而可以作為人類成骨細胞樣細胞的永生細胞系及骨相關分子的來源。Saos-2細胞的模態染色體數為56,超過三分之二的染色體組由重排的染色體組成,大多數的標記染色體具有復雜的重排結構,並且無法識別組成這些的片段來源。 (zh)
  • Saos-2 ("Sarcoma osteogenic") is a cell line derived from the primary osteosarcoma of an 11-year-old Caucasian girl in 1973 by Fogh et al. The cell line is commonly used in bone cancer research as a model for testing novel therapies. In 1987 Rodan et al. determined that Saos-2 cells "possess several osteoblastic features and could be useful as a permanent line of human osteoblast-like cells and as a source of bone-related molecules." (en)
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  • Cèl·lules SaOS-2 (de l'anglès "Sarcoma osteogenic") és una línia cel·lular derivada de l'osteosarcoma primari d'una nena caucàsica d'11 anys. Es va obtenir l'any 1973 per Fogh et al. La línia cel·lular s'utilitza habitualment en la investigació del càncer d'os com a model per provar noves teràpies. El 1987 Rodan et al. va determinar que les cèl·lules Saos-2 "posseeixen diverses característiques osteoblàstiques i podrien ser útils com a línia permanent de cèl·lules semblants als osteoblasts humans i com a font de molècules relacionades amb els ossos". A banda de ser fàcilment disponibles a nivell mundial, alguns dels avantatges d'utilitzar la línia cel·lular Saos-2 són l'existència de dades de caracterització ben documentades, la possibilitat d'obtenir-ne grans quantitats en poc temps i el fet que les cèl·lules Saos-2 es poden diferenciar completament tal com ho fan les cèl·lules osteoblàstiques de manera natural. Aquest últim punt es descriu particularment com "la capacitat de les cèl·lules Saos-2 per dipositar una matriu extracel·lular competent en mineralització", que fa d'aquestes cèl·lules un model valuós per estudiar esdeveniments associats a l'etapa tardana de diferenciació osteoblàstica en cèl·lules humanes. (ca)
  • Saos-2 ("Sarcoma osteogenic") is a cell line derived from the primary osteosarcoma of an 11-year-old Caucasian girl in 1973 by Fogh et al. The cell line is commonly used in bone cancer research as a model for testing novel therapies. In 1987 Rodan et al. determined that Saos-2 cells "possess several osteoblastic features and could be useful as a permanent line of human osteoblast-like cells and as a source of bone-related molecules." Besides their worldwide availability, some of the advantages for using Saos-2 cell line are that they have well-documented characterization data, the possibility to obtain large amounts of cells in short time, and the fact that Saos-2 cells can be fully differentiated in a manner that the osteoblastic cells naturally do. The latter point is described particularly as "the ability of Saos-2 cells to deposit a mineralization-competent extracellular matrix", which makes these cells a valuable model for studying events associated with the late osteoblastic differentiation stage in human cells. (en)
  • Saos-2是一種人類骨肉瘤細胞系,通常在骨癌研究中用作研究新療法的模型,最初是在1973年分離自一名11歲白人女性原發性骨肉瘤中患者,而該患者已接受氨甲蝶呤、阿黴素及長春新鹼等的治療。 1987年,科研人員發現細胞對副甲狀腺激素顯示敏感的腺苷酸環化酶反應,隨細胞密度增加而增加,並且通過地塞米松(一種人工合成的皮質類固醇)治療進一步提高。隨後確定Saos-2細胞具有數個成骨細胞的特徵,故而可以作為人類成骨細胞樣細胞的永生細胞系及骨相關分子的來源。Saos-2細胞的模態染色體數為56,超過三分之二的染色體組由重排的染色體組成,大多數的標記染色體具有復雜的重排結構,並且無法識別組成這些的片段來源。 (zh)
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