The term S/MAR (scaffold/matrix attachment region), otherwise called SAR (scaffold-attachment region), or MAR (matrix-associated region), are sequences in the DNA of eukaryotic chromosomes where the nuclear matrix attaches. As architectural DNA components that organize the genome of eukaryotes into functional units within the cell nucleus, S/MARs mediate structural organization of the chromatin within the nucleus. These elements constitute anchor points of the DNA for the chromatin scaffold and serve to organize the chromatin into structural domains. Studies on individual genes led to the conclusion that the dynamic and complex organization of the chromatin mediated by S/MAR elements plays an important role in the regulation of gene expression.
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| - Kerngerüst-/Kernmatrixanheftungsregionen (de)
- Regione di attacco alla matrice nucleare (it)
- Matrix Attachment Regions (fr)
- Scaffold/matrix attachment region (en)
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| - The term S/MAR (scaffold/matrix attachment region), otherwise called SAR (scaffold-attachment region), or MAR (matrix-associated region), are sequences in the DNA of eukaryotic chromosomes where the nuclear matrix attaches. As architectural DNA components that organize the genome of eukaryotes into functional units within the cell nucleus, S/MARs mediate structural organization of the chromatin within the nucleus. These elements constitute anchor points of the DNA for the chromatin scaffold and serve to organize the chromatin into structural domains. Studies on individual genes led to the conclusion that the dynamic and complex organization of the chromatin mediated by S/MAR elements plays an important role in the regulation of gene expression. (en)
- Les MARs ou Matrix Attachment Regions sont des séquences d’ADN eucaryote associéesà la matrice nucléaire pendant l’interphase . Ces éléments jouent un rôle dans la structure de la chromatine, en organisant le génome des cellules eucaryotes en boucles indépendantes de chromatine. Une telle ségrégation de la chromatine permet de former des régions d’ADN décompacté, plus accessible à la machinerie de transcription. (fr)
- Le regioni di attacco alla matrice (MAR), conosciute anche come regioni di attacco allo scaffold/matrice (S/MARs), sono sequenze di DNA nei cromosomi degli eucarioti a cui si lega la matrice nucleare. Le S/MAR mediano l'organizzazione strutturale della cromatina all'interno del nucleo. Questi elementi costituiscono punti in cui il DNA si ancora allo scaffold cromatinico e servono per organizzare la cromatina in domini strutturali. Studi su singoli geni hanno portato alla conclusione che la dinamica e complessa organizzazione della cromatina mediata dagli elementi S/MAR gioca un ruolo importante nella regolazione dell'espressione genica. (it)
- Kerngerüst-/Kernmatrixanheftungsregionen (engl. scaffold/matrix attachment region, S/MAR), auch scaffold-attachment region (SAR) oder matrix-associated element (MAR) genannt, sind DNA-Sequenzen von eukaryotischen Chromosomen bzw. der 30-nm-Faser oder des Chromatins, die sich an der Kernmatrix anheften. Man kann S/MARs durchaus als architektonische DNA-Komponenten bezeichnet, die sowohl einen organisatorischen Einfluss auf das Genom haben, als auch die Aktivierung und Inaktivierung von Genomabschnitten beeinflussen und ebenfalls die strukturelle Organisation mit beeinflussen, d. h. die Kondensation des Chromatins innerhalb des Zellkerns. Diese Elemente bilden Ankerpunkte der DNA für das Chromatingerüst und dienen dazu, das Chromatin in Strukturdomänen anzuordnen. Studien über individuelle G (de)
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| - Kerngerüst-/Kernmatrixanheftungsregionen (engl. scaffold/matrix attachment region, S/MAR), auch scaffold-attachment region (SAR) oder matrix-associated element (MAR) genannt, sind DNA-Sequenzen von eukaryotischen Chromosomen bzw. der 30-nm-Faser oder des Chromatins, die sich an der Kernmatrix anheften. Man kann S/MARs durchaus als architektonische DNA-Komponenten bezeichnet, die sowohl einen organisatorischen Einfluss auf das Genom haben, als auch die Aktivierung und Inaktivierung von Genomabschnitten beeinflussen und ebenfalls die strukturelle Organisation mit beeinflussen, d. h. die Kondensation des Chromatins innerhalb des Zellkerns. Diese Elemente bilden Ankerpunkte der DNA für das Chromatingerüst und dienen dazu, das Chromatin in Strukturdomänen anzuordnen. Studien über individuelle Gene führten zu der Schlussfolgerung, dass die durch S/MARs vermittelte, komplexe und dynamische Organisation des Chromatins bei der Regulation der Genexpression eine wichtige Rolle spielt. (de)
- The term S/MAR (scaffold/matrix attachment region), otherwise called SAR (scaffold-attachment region), or MAR (matrix-associated region), are sequences in the DNA of eukaryotic chromosomes where the nuclear matrix attaches. As architectural DNA components that organize the genome of eukaryotes into functional units within the cell nucleus, S/MARs mediate structural organization of the chromatin within the nucleus. These elements constitute anchor points of the DNA for the chromatin scaffold and serve to organize the chromatin into structural domains. Studies on individual genes led to the conclusion that the dynamic and complex organization of the chromatin mediated by S/MAR elements plays an important role in the regulation of gene expression. (en)
- Les MARs ou Matrix Attachment Regions sont des séquences d’ADN eucaryote associéesà la matrice nucléaire pendant l’interphase . Ces éléments jouent un rôle dans la structure de la chromatine, en organisant le génome des cellules eucaryotes en boucles indépendantes de chromatine. Une telle ségrégation de la chromatine permet de former des régions d’ADN décompacté, plus accessible à la machinerie de transcription. (fr)
- Le regioni di attacco alla matrice (MAR), conosciute anche come regioni di attacco allo scaffold/matrice (S/MARs), sono sequenze di DNA nei cromosomi degli eucarioti a cui si lega la matrice nucleare. Le S/MAR mediano l'organizzazione strutturale della cromatina all'interno del nucleo. Questi elementi costituiscono punti in cui il DNA si ancora allo scaffold cromatinico e servono per organizzare la cromatina in domini strutturali. Studi su singoli geni hanno portato alla conclusione che la dinamica e complessa organizzazione della cromatina mediata dagli elementi S/MAR gioca un ruolo importante nella regolazione dell'espressione genica. (it)
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