Scotch Run is one of the main tributaries of Catawissa Creek in Columbia County, Pennsylvania, in the United States. It is approximately 7.8 miles (12.6 km) long and flows through Beaver Township and Main Township. The stream's watershed has an area of 9.10 square miles (23.6 km2). The stream is infertile and acidic. It is 7.2 feet (2.2 m) wide in its upper reaches and 17.0 feet (5.2 m) wide in its lower reaches. The main rock formations in the watershed include the Mauch Chunk Formation, the Pocono Formation, the Pottsville Formation, and the Spechty Kopf Formation. The main soils include Leck Kill soil and Hazleton soil. It flows between Nescopeck Mountain and McCauley Mountain.