About: Sea anemone neurotoxin

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Sea anemone neurotoxin is the name given to neurotoxins produced by sea anemones with related structure and function.Sea anemone neurotoxins can be divided in two functional groups that either specifically target the sodium channel or the potassium channel. The potassium channel toxin family include kaliseptine and kalicludines, and was also isolated from Anemonia viridis.

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein yago:Abstraction100002137 yago:Attribute100024264 yago:Chemical114806838 yago:Compound114818238 yago:Environment113934596 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 protein yago:Situation113927383 yago:Sphere114514039 yago:State100024720 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatPeripheralMembraneProteins yago:WikicatProteinDomains
rdfs:label	Sea anemone neurotoxin (en)
rdfs:comment	Sea anemone neurotoxin is the name given to neurotoxins produced by sea anemones with related structure and function.Sea anemone neurotoxins can be divided in two functional groups that either specifically target the sodium channel or the potassium channel. The potassium channel toxin family include kaliseptine and kalicludines, and was also isolated from Anemonia viridis. (en)
name	Anemone neurotoxin (en) Antihypertensive protein BDS-I/II (en)
foaf:depiction
dcterms:subject	Peripheral membrane proteins Neurotoxins Protein domains Sea anemone toxins
Wikipage page ID	14846478 (xsd:integer)
Wikipage revision ID	1051655325 (xsd:integer)
Link from a Wikipage to another Wikipage	Calitoxin Anthopleurin Antiviral protein Crustacean Anemonia sulcata Halcurin Peripheral membrane proteins Kaliseptine Neurotoxins Protein domains AETX Sea anemone toxins Axon Cangitoxin Sea anemone Neurotoxin Sodium channel Snakelocks anemone Antihypertensive
sameAs	Sea anemone neurotoxin Sea anemone neurotoxin Sea anemone neurotoxin Sea anemone neurotoxin
dbp:wikiPageUsesTemplate	dbt:Membrane-protein-stub dbt:InterPro_content dbt:Reflist dbt:Uniprot dbt:Pfam_box
thumbnail	wiki-commons:Special:FilePath/PDB_1atx_EBI.jpg?width=300
SCOP	1 (xsd:integer) 2 (xsd:integer)
caption	Structure of the neurotoxin ATX Ia from Anemonia sulcata. (en) Structure of the antihypertensive and antiviral protein BDS-I from the sea anemone Anemonia sulcata. (en)
InterPro	IPR000693 (en) IPR012414 (en)
Pfam	PF00706 (en) PF07936 (en)
Pfam clan	CL0075 (en)
symbol	Toxin_4 (en) BDS_I_II (en)
has abstract	Sea anemone neurotoxin is the name given to neurotoxins produced by sea anemones with related structure and function.Sea anemone neurotoxins can be divided in two functional groups that either specifically target the sodium channel or the potassium channel. A number of proteins belong to the sodium channel toxin family, including calitoxin and anthopleurin. The neurotoxins bind specifically to the sodium channel, thereby delaying its inactivation during signal transduction, resulting in strong stimulation of mammalian cardiac muscle contraction. Calitoxin 1 has been found in neuromuscular preparations of crustaceans, where it increases transmitter release, causing firing of the axons. Three disulfide bonds are present in this protein. This family also includes the antihypertensive and antiviral proteins BDS-I (P11494) and BDS-II (P59084) expressed by Anemonia viridis (previously Anemonia sulcata). BDS-I is organised into a triple-stranded antiparallel beta-sheet, with an additional small antiparallel beta-sheet at the N-terminus. Both peptides are known to specifically block the Kv3.4 potassium channel, and thus bring about a decrease in blood pressure. Moreover, they inhibit the cytopathic effects of mouse hepatitis virus strain MHV-A59 on mouse liver cells, by an unknown mechanism. The potassium channel toxin family include kaliseptine and kalicludines, and was also isolated from Anemonia viridis. (en)
OPM family	54 (xsd:integer)
OPM protein	1 (xsd:integer)
gold:hypernym	Name
prov:wasDerivedFrom	wikipedia-en:Sea_anemone_neurotoxin?oldid=1051655325&ns=0
page length (characters) of wiki page	5742 (xsd:nonNegativeInteger)
Symbol	Toxin_4 BDS_I_II
foaf:isPrimaryTopicOf	wikipedia-en:Sea_anemone_neurotoxin
is Link from a Wikipage to another Wikipage of	Calitoxin BcIII Defensin Halcurin ATX-II Cangitoxin Sea anemone Neurotoxin B-IV Versutoxin
is foaf:primaryTopic of	wikipedia-en:Sea_anemone_neurotoxin

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