About: Setanaxib

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Setanaxib (development code GKT-831) is an experimental orally bioavailable dual inhibitor of NADPH oxidase isoforms NOX4 and NOX1. Setanaxib is a member of the chemical series. The compound is the only specific that has entered into clinical trials.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Drug drug
rdfs:label	Setanaxib (en)
rdfs:comment	Setanaxib (development code GKT-831) is an experimental orally bioavailable dual inhibitor of NADPH oxidase isoforms NOX4 and NOX1. Setanaxib is a member of the chemical series. The compound is the only specific that has entered into clinical trials. (en)
foaf:depiction
dcterms:subject	Pyrazolopyridines Chloroarenes Dimethylamino compounds Orphan drugs Anilines
Wikipage page ID	54042070 (xsd:integer)
Wikipage revision ID	1115334589 (xsd:integer)
Link from a Wikipage to another Wikipage	Pulmonary hypertension Biopsy Pyrazolopyridines Pembrolizumab University of Alabama at Birmingham School of Medicine Ursodeoxycholic acid Binding affinity Chloroarenes Dimethylamino compounds NOX1 Phase 1 clinical testing Stockholm Clinical trial Idiopathic pulmonary fibrosis Primary biliary cholangitis Gamma-glutamyltransferase Alkaline phosphatase Orphan drugs Drug safety FDA dbr:Nintedanib Osteoporosis Diabetic nephropathy Anilines Atherosclerosis Archamps Albuminuria Bioavailability High-throughput screening Pirfenidone Fibrosis Immunotherapy National Institutes of Health Cancer-associated fibroblast Pharmacokinetics NADPH oxidase Retinopathy NOX4 Transient elastography Squamous cell carcinoma Squamous cell carcinoma of the head and neck Orphan drug designation Rational drug design Diabetic kidney disease Liver fibrosis dbr:NOX_inhibitor dbr:Pyrazolopyridine_dione
Link from a Wikipage to an external page	https://jdrf.org.uk/ https://en-us.transform-study.com/ https://www.calliditas.se/en/
sameAs	Setanaxib Setanaxib
dbp:wikiPageUsesTemplate	dbt:Drugbox dbt:Reflist dbt:Short_description dbt:Fdacite
thumbnail	wiki-commons:Special:FilePath/Setanaxib.png?width=300
c	21 (xsd:integer)
CAS number	1218942 (xsd:integer)
ChemSpiderID	29785291 (xsd:integer)
Cl	1 (xsd:integer)
H	19 (xsd:integer)
IUPAC name	2 (xsd:integer)
legal status	Investigational (en)
n	4 (xsd:integer)
O	2 (xsd:integer)
SMILES	CN1CC=C2CCNC4=CC=CC=C4Cl (en)
StdInChI	1 (xsd:integer)
StdInChIKey	RGYQPQARIQKJKH-UHFFFAOYSA-N (en)
synonyms	GKT-831 (en)
UNII	45 (xsd:integer)
has abstract	Setanaxib (development code GKT-831) is an experimental orally bioavailable dual inhibitor of NADPH oxidase isoforms NOX4 and NOX1. Setanaxib is a member of the chemical series. The compound is the only specific that has entered into clinical trials. Setanaxib has demonstrated biological activity in a number of in vitro and in vivo animal pharmacological models including squamous cell carcinoma of the head and neck, diabetic nephropathy, retinopathy, atherosclerosis, liver fibrosis, osteoporosis, pulmonary hypertension, and idiopathic pulmonary fibrosis. This drug candidate has been investigated in humans in a Phase 2 proof-of-concept trial in primary biliary cholangitis and a Phase 2 proof-of-concept trial in diabetic nephropathy. Setanaxib was developed by Genkyotex, a French biotech company based in Archamps. In 2020, Calliditas Therapeutics AB acquired a controlling interest in Genkyotex, which was delisted and became a fully owned subsidiary of Calliditas in October 2021. Calliditas, a commercial stage biotech company headquartered in Stockholm, is currently developing setanaxib in two clinical trials in human patients. (en)
prov:wasDerivedFrom	wikipedia-en:Setanaxib?oldid=1115334589&ns=0
page length (characters) of wiki page	15607 (xsd:nonNegativeInteger)
CAS number	1218942-37-0
FDA UNII code	45II35329V
foaf:isPrimaryTopicOf	wikipedia-en:Setanaxib
is Link from a Wikipage to another Wikipage of	GKT-831 GKT137831 Glossary of chemical formulae C21H19ClN4O2
is Wikipage redirect of	GKT-831 GKT137831
is foaf:primaryTopic of	wikipedia-en:Setanaxib

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