Seymour Horace Knox I (April 1861 – May 17, 1915), was a Buffalo, New York businessman who made his fortune in five-and-dime stores. He merged his more than 100 stores with those of his first cousins, Frank Winfield Woolworth and Charles Woolworth, to form the F. W. Woolworth Company. He went on to hold prominent positions in the merged company as well as Marine Trust Co. He was the father of Seymour H. Knox II and grandfather of Seymour H. Knox III and Northrup Knox, the co-founders of the Buffalo Sabres in the National Hockey League.