Shlomo Moussaieff (1852 – 1922) was a rabbi and gemstone trader, from Bukhara, in what is today Uzbekistan. He was one of the founders of the Bukharim neighborhood in Jerusalem. He was also the patriarch of the Moussaieff clan, which includes such notable personalities as Shlomo Moussaieff of London, Dorrit Moussaieff of Iceland, and Jeffrey Moussaieff Masson.