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Sibrafiban (Ro 48–3657, proposed brand name Xubix) is the double prodrug of Ro-44-3888, which is a platelet aggregation inhibitor. It was being developed for secondary prevention of arterial thrombosis following unstable angina pectoris and acute myocardial infarction (MI). On August 6, 1999, Hoffmann-La Roche announced that the preliminary results from Phase III clinical trials had not shown that sibrafiban was better than aspirin in preventing recurrent ischemic events in patients with acute coronary syndrome. The development of sibrafiban was terminated.

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  • Sibrafiban (en)
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  • Sibrafiban (Ro 48–3657, proposed brand name Xubix) is the double prodrug of Ro-44-3888, which is a platelet aggregation inhibitor. It was being developed for secondary prevention of arterial thrombosis following unstable angina pectoris and acute myocardial infarction (MI). On August 6, 1999, Hoffmann-La Roche announced that the preliminary results from Phase III clinical trials had not shown that sibrafiban was better than aspirin in preventing recurrent ischemic events in patients with acute coronary syndrome. The development of sibrafiban was terminated. (en)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/Sibrafiban_structure.svg
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IUPAC name
  • [Z]--[‌[1-[2-[‌[4--benzoyl]amino]-1-oxopropyl]-4-piperidinyl]oxyl]-acetic ethyl ester (en)
KEGG
  • D05834 (en)
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PubChem
SMILES
  • CCOCCOC1CCNC[C@H]NCc2cccCNO (en)
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  • WBNUCLPUOSXSNJ-ZDUSSCGKSA-N (en)
UNII
  • YUE443B0NF (en)
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  • Sibrafiban (Ro 48–3657, proposed brand name Xubix) is the double prodrug of Ro-44-3888, which is a platelet aggregation inhibitor. It was being developed for secondary prevention of arterial thrombosis following unstable angina pectoris and acute myocardial infarction (MI). On August 6, 1999, Hoffmann-La Roche announced that the preliminary results from Phase III clinical trials had not shown that sibrafiban was better than aspirin in preventing recurrent ischemic events in patients with acute coronary syndrome. The development of sibrafiban was terminated. (en)
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CAS number
  • 170094-62-9
ChEMBL
  • 435176
FDA UNII code
  • YUE443B0NF
KEGG
  • D05834
PubChem
  • 5491394
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