Sir Thomas Littleton, 2nd Baronet (c. 1621 – 14 April 1681) was an English politician from the extended Littleton/Lyttelton family who sat in the House of Commons variously between 1640 and 1681. Littleton was the son of Sir Adam Littleton, 1st Baronet of Stoke St. Milborough, Shropshire and his wife Audrey Poyntz daughter of Thomas Poyntz. He studied at Jesus College, Oxford, but did not graduate.