Blandina Segale, more commonly known as Sister Blandina (23 January 1850 – 23 February 1941) was an Italian-born American Sister of Charity of Cincinnati and missionary, who became widely known through her service on the American frontier in the late 19th century. During her missionary work, she met, among others, Billy the Kid and the leaders of the Native American tribes of the Apache and Comanche. She served as an educator and social worker who worked in Ohio, Colorado and New Mexico, assisting Native Americans, Hispanic settlers and European immigrants.