About: Small tumor antigen

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The small tumor antigen (also called the small T-antigen and abbreviated STag or ST) is a protein encoded in the genomes of polyomaviruses, which are small double-stranded DNA viruses. STag is expressed early in the infectious cycle and is usually not essential for viral proliferation, though in most polyomaviruses it does improve replication efficiency. The STag protein is expressed from a gene that overlaps the large tumor antigen (LTag) such that the two proteins share an N-terminal DnaJ-like domain but have distinct C-terminal regions. STag is known to interact with host cell proteins, most notably protein phosphatase 2A (PP2A), and may activate the expression of cellular proteins associated with the cell cycle transition to S phase. In some polyomaviruses - such as the well-studied SV

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rdfs:label	Small tumor antigen (en)
rdfs:comment	The small tumor antigen (also called the small T-antigen and abbreviated STag or ST) is a protein encoded in the genomes of polyomaviruses, which are small double-stranded DNA viruses. STag is expressed early in the infectious cycle and is usually not essential for viral proliferation, though in most polyomaviruses it does improve replication efficiency. The STag protein is expressed from a gene that overlaps the large tumor antigen (LTag) such that the two proteins share an N-terminal DnaJ-like domain but have distinct C-terminal regions. STag is known to interact with host cell proteins, most notably protein phosphatase 2A (PP2A), and may activate the expression of cellular proteins associated with the cell cycle transition to S phase. In some polyomaviruses - such as the well-studied SV (en)
foaf:depiction
dcterms:subject	Viral oncoproteins Polyomavirus proteins
Wikipage page ID	53256270 (xsd:integer)
Wikipage revision ID	1093318724 (xsd:integer)
Link from a Wikipage to another Wikipage	Messenger RNA Mutation Merkel cell polyomavirus Cytoplasm DNA-binding protein DNA replication JC virus dbr:P53 Essential gene Viral oncoproteins Gene expression Genome dbr:Retinoblastoma_protein Oncovirus Genus (biology) Murine polyomavirus Animal model Skin cancer Zinc Middle tumor antigen Polyomavirus proteins Helicase Large tumor antigen Cysteine Alternative splicing Cell cycle Protein complex Protein ATPase Double-stranded DNA virus Oncogenesis Sequence motif X-ray crystallography Sequence homology Merkel cell carcinoma S phase Exon Subcellular localization Phosphorylation Protein phosphatase 2A Iron-sulfur cluster SV40 Cap-dependent translation Protein stability Translation initiation factor Host cell Hsc70 Oncoprotein DnaJ Gene promoter Polyomavirus 4E-BP1 N-terminal Molecular chaperone Capsid protein Neoplastic transformation dbr:Gammapolyomavirus
sameAs	Small tumor antigen Small tumor antigen Small tumor antigen
dbp:wikiPageUsesTemplate	dbt:Multiple_image dbt:Reflist dbt:Viral_proteins
thumbnail	wiki-commons:Special:FilePath/2pf4_stag.png?width=300
align	right (en)
caption	The SV40 polyomavirus small tumor antigen J domain and unique region in complex with the human protein phosphatase 2A A subunit . (en) The human protein phosphatase 2A heterotrimeric complex, shown with the regulatory subunit A , regulatory subunit B56 , and catalytic subunit . The overlap between the STag and B56 binding sites on the A subunit is clear. (en)
direction	vertical (en)
image	2 (xsd:integer)
has abstract	The small tumor antigen (also called the small T-antigen and abbreviated STag or ST) is a protein encoded in the genomes of polyomaviruses, which are small double-stranded DNA viruses. STag is expressed early in the infectious cycle and is usually not essential for viral proliferation, though in most polyomaviruses it does improve replication efficiency. The STag protein is expressed from a gene that overlaps the large tumor antigen (LTag) such that the two proteins share an N-terminal DnaJ-like domain but have distinct C-terminal regions. STag is known to interact with host cell proteins, most notably protein phosphatase 2A (PP2A), and may activate the expression of cellular proteins associated with the cell cycle transition to S phase. In some polyomaviruses - such as the well-studied SV40, which natively infects monkeys - STag is unable to induce neoplastic transformation in the host cell on its own, but its presence may increase the transforming efficiency of LTag. In other polyomaviruses, such as Merkel cell polyomavirus, which causes Merkel cell carcinoma in humans, STag appears to be important for replication and to be an oncoprotein in its own right. (en)
prov:wasDerivedFrom	wikipedia-en:Small_tumor_antigen?oldid=1093318724&ns=0
page length (characters) of wiki page	17317 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Small_tumor_antigen
is Link from a Wikipage to another Wikipage of	MW polyomavirus Merkel cell polyomavirus WU polyomavirus Murine polyomavirus Hamster polyomavirus Middle tumor antigen Agnoprotein Large tumor antigen KI polyomavirus Merkel-cell carcinoma New Jersey polyomavirus Trichodysplasia spinulosa polyomavirus Polyomaviridae Sorex araneus polyomavirus 1 STL polyomavirus

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