South Carolina Highway 101 (SC 101) is a 56.522-mile (90.963 km) state highway in Laurens, Spartanburg, and Greenville counties in the U.S. state of South Carolina. Its southern terminus is at an intersection with U.S. Route 76 (US 76) in Hickory Tavern, and its northern terminus is at an intersection with SC 11 near Landrum.